中国免疫学杂志2025，Vol.41Issue(9)：2081-2086,6.DOI:10.3969/j.issn.1000-484X.2025.09.006
41种细胞因子和生长因子与血清阴性的类风湿关节炎的因果关系:一项双样本孟德尔随机化研究
Association of 41 circulating interleukins and growth factors with risk of seronegative rheumatoid arthritis:A Mendelian randomization study
摘要
Abstract
Objective:To explore the association of serum levels of 41 serum cytokines and growth factors with the risk of sero-negative rheumatoid arthritis(SNRA)by Mendelian randomization.Methods:Genetic instruments for 41 circulating cytokines and growth factors were determined from a genome-wide association study(GWAS)of 8 293 European participants.Summary statistics for the SNRA were obtained from the Finnish database,including 3 877 SNRA cases and 285 035 controls of European ancestry.All of the inverse variance weighted(IVW),weighted median method(WM)and MR-Egger regression were used for MR analysis,while the IVW method was considered as the main analysis.The sensitivity analysis included a heterogeneity test,horizontal pleiotropic test,and leave-one method test to determine the reliability of the MR results.Results:In the IVW method,TNF-α[OR=1.470,95%CI(1.1331～1.910),P=0.004],IP-10[OR=0.794,95%CI(0.660～0.955),P=0.015]and IL-2rα[OR=0.049,95%CI(0.856～0.999),P=0.049].Sensitivity analysis showed no heterogeneity and horizontal pleiotropy.Conclusion:TNF-α,IP-10 and IL-2rα are causally associated to SNRA.TNF-α increases the risk of SNRA,while IP-10 and IL-2rα reduce the risk of SNRA.关键词
血清细胞因子/血清阴性的类风湿关节炎/孟德尔随机化/因果关系Key words
Serum cytokines/Seronegative rheumatoid arthritis/Mendelian randomization/Causality分类
医药卫生引用本文复制引用
凌益,任妮娜,王秋燚,姚血明,马武开..41种细胞因子和生长因子与血清阴性的类风湿关节炎的因果关系:一项双样本孟德尔随机化研究[J].中国免疫学杂志,2025,41(9):2081-2086,6.基金项目
国家自然科学基金(82274678,82160869,82405366) （82274678,82160869,82405366）
贵州省科技计划项目[黔科合平台人才(2020)2202,黔科合支撑(2021)一般006,黔科合基础-ZK(2023)一般412,黔科合成果LC(2025)一般021] （2020）
贵科合学术新苗项目(2023-36) （2023-36）
贵州中医药大学国家与省级科技创新人才团队培育项目[贵中医TD合字(2022)004号] （2022）
贵州中医药大学第二附属医院"三航"人才培养工程(SHRC-KY2024018). （SHRC-KY2024018）
