中国免疫学杂志2025，Vol.41Issue(9)：2098-2105,8.DOI:10.3969/j.issn.1000-484X.2025.09.009
桥本甲状腺炎:免疫学发病机制的进展
Hashimoto's thyroiditis:Advances in immunological pathogenesis
摘要
Abstract
Hashimoto's thyroiditis(HT)is an organ-specific autoimmune disease characterized by a diffuse infiltration of lymphocytes in thyroid tissue.In recent years,incidence of HT has gradually increased and is a major cause of hypothyroidism in popu-lations in areas with adequate iodine intake,which can affect the quality of life of patients.A large number of studies have suggested that cellular and humoral immunity,related immune molecules and other factors affecting the immune response together constitute a complex network of immune regulation involved in the development of HT.With the development of immunology and other disciplines,the study of the immunological pathogenesis of HT is crucial to uncover its specific diagnostic criteria and treatment,and therefore,many researchers have focused on this issue and proposed new ideas.In this article,we review the advances of research on immunolog-ical pathogenesis of HT.关键词
桥本甲状腺炎/自身免疫病/发病机制/致病因素Key words
Hashimoto's thyroiditis/Autoimmune diseases/Pathogenesis/Pathogenic factors分类
医药卫生引用本文复制引用
李奕,汤子媚,王容,明洁..桥本甲状腺炎:免疫学发病机制的进展[J].中国免疫学杂志,2025,41(9):2098-2105,8.基金项目
国家自然科学基金(82270830) （82270830）
湖北省自然科学基金(2022CFB072). （2022CFB072）
