中国免疫学杂志2025，Vol.41Issue(9)：2117-2122,6.DOI:10.3969/j.issn.1000-484X.2025.09.011
白细胞介素-27在类风湿关节炎中的研究进展
Research progress of interleukin-27 in rheumatoid arthritis
摘要
Abstract
Rheumatoid arthritis(RA)is an autoimmune disease characterized by joint synovium inflammation and hyperpla-sia.IL-27 is a heterodimeric cytokine composed of p28 and EBI3.The binding of IL-27 to IL-27R leads to activation of JAK/STAT and p38/MAPK pathways,which plays anti-inflammatory and pro-inflammatory roles in the regulation of T/B cell differentiation and im-mune response,and participates in the occurrence and development of RA.In this paper,we have reviewed the structural characteris-tics,biological functions and research progress of IL-27,providing directions for exploring the pathogenesis and new therapeutic tar-gets of RA.关键词
类风湿关节炎/IL-27/炎症免疫反应/信号转导Key words
Rheumatoid arthritis/IL-27/Inflammatory immune response/Signal transduction分类
医药卫生引用本文复制引用
韩乐,张贤政,张玲玲..白细胞介素-27在类风湿关节炎中的研究进展[J].中国免疫学杂志,2025,41(9):2117-2122,6.基金项目
国家自然科学基金项目(82204403) （82204403）
徐州医科大学附属医院发展基金项目(XYFY2020021). （XYFY2020021）
