中国免疫学杂志2025，Vol.41Issue(9)：2123-2130,8.DOI:10.3969/j.issn.1000-484X.2025.09.012
A20在类风湿关节炎中的作用机制研究及中医药干预进展
Mechanism of A20 in rheumatoid arthritis and progress of Chinese medicine intervention
摘要
Abstract
Rheumatoid arthritis(RA)is an autoimmune disease characterized by chronic,aggressive joint inflammation,which seriously harms mental and physical health of patients.Efficacy of clinical drugs for RA is limited,so it is a hot issue to seek new therapeutic targets and drugs.Zinc finger protein A20,a cytoplasmic ubiquitin modifier,is closely related to negative regulation of nuclear factor-kappaB(NF-κB),an inflammatory signaling pathway,and has anti-inflammatory and anti-apoptotic effects.A20 is involved in pathogenesis of RA and can improve inflammatory response and bone destruction of RA.Treatment of RA by traditional Chinese medicine has unique advantages of multi-target and multi-pathway,and studies have found that traditional Chinese medicine has a regulatory effect on A20.This paper expounds mechanism of A20 in RA and research progress of traditional Chinese medicine intervention in A20,in order to provide references for treatment and drug development of RA.关键词
锌指蛋白A20/类风湿关节炎/中医药/NF-κBKey words
Zinc finger protein A20/Rheumatoid arthritis/Traditional Chinese medicine/NF-κB分类
医药卫生引用本文复制引用
吴伊莹,柳玉佳,郑蕾,刘梨,陈新怡,郭志华..A20在类风湿关节炎中的作用机制研究及中医药干预进展[J].中国免疫学杂志,2025,41(9):2123-2130,8.基金项目
国家自然科学基金面上项目(82274627) （82274627）
湖南省自然科学基金项目(2023JJ40508) （2023JJ40508）
湖南省教育厅科研项目(21B0370) （21B0370）
湖南省中医药管理局科研项目(D2022123). （D2022123）
