中国全科医学2025，Vol.28Issue(31)：3942-3947,6.DOI:10.12114/j.issn.1007-9572.2025.0043
饮酒情况对阿尔茨海默病患者大脑结构变化的影响:基于体素大脑形态学分析
The Impact of Alcohol Consumption Habits on Brain Structural Changes in Alzheimer's Disease:a Voxel-based Morphometry Study
摘要
Abstract
Background Alzheimer's disease(AD),the most common type of dementia,poses a significant threat to the global elderly population.In recent years,alcohol consumption in China has been steadily increasing.As a potential lifestyle factor,drinking behavior may influence AD progression,but the relationship with AD-related brain changes remains insufficiently understood.Objective To investigate the impact of alcohol consumption on brain structural changes in AD patients using voxel-based morphometry(VBM)analysis.Methods Data were retrospectively collected from AD patients hospitalized at Huashan Hospital,Fudan University,between 2020 and 2023.Information on alcohol consumption,brain MRI scans,and other clinical variables was obtained through medical records and telephone follow-up.A total of 66 AD patients with complete data were included in the analysis.Patients were stratified by disease severity(based on Mini-mental State Examination scores)and drinking status into mild-to-moderate AD with and without a history of alcohol consumption,severe AD with and without a history of alcohol consumption.VBM was used to compare differences in gray matter volume(GMV)among the groups.Results Among the 66 patients,42 had mild-to-moderate AD,and 24 had severe AD.Among the mild-to-moderate group,16 had a history of alcohol consumption and 26 did not.Among patients with mild to moderate AD,the proportion of males with a history of alcohol consumption and the proportion of those with a history of smoking were higher than those without such histories(P<0.05).Among the 24 patients with severe AD,9 had a history of alcohol consumption and 15 did not.Among the patients with severe AD,the proportion of males with a history of alcohol consumption and the proportion of those with a history of smoking were higher than those without a history of alcohol consumption(P<0.05).In patients with mild to moderate AD,the GMV of the right angular gyrus in those without a history of alcohol consumption was lower than that in those with a history of alcohol consumption(t=-3.698,P<0.05).In patients with severe AD who had a history of alcohol consumption,the GMV of the left superior temporal gyrus was lower than that of those without a history of alcohol consumption(t=5.774,P<0.05).Conclusion A history of alcohol consumption appears to significantly influence patterns of gray matter atrophy in AD patients.In mild-to-moderate AD,drinking may be associated with attenuated atrophy in the right angular gyrus,whereas in severe AD,it is linked to increased atrophy in the left superior temporal gyrus.These findings suggest a dual role of alcohol consumption in the progression of AD.关键词
阿尔茨海默病/酒精摄入量/结构磁共振成像/大脑形态学/认知障碍Key words
Alzheimer's disease/Alcohol consumption/Structural magnetic resonance imaging/Brain morphology/Cognitive impairment分类
医药卫生引用本文复制引用
邱鲲羽,顾洁,范梅香,邓燕,刘轶蕾,黄延焱..饮酒情况对阿尔茨海默病患者大脑结构变化的影响:基于体素大脑形态学分析[J].中国全科医学,2025,28(31):3942-3947,6.基金项目
科技创新2030-脑科学与类脑研究重大项目(2022ZD0211600) （2022ZD0211600）
