中国全科医学2025，Vol.28Issue(32)：4047-4054,8.DOI:10.12114/j.issn.1007-9572.2025.0070
相对脂肪量与中老年人群心血管疾病之间的关联:一项基于CHARLS的横断面与纵向研究
Association between Relative Fat Mass and Cardiovascular Disease in Middle-aged and Elderly Population:a Cross-sectional and Longitudinal Study Based on CHARLS
摘要
Abstract
Background In recent years,an association has been found between the relative fat mass(RFM)and cardiovascular disease(CVD).However,nationwide cohort studies on RFM and the risk of CVD in the Chinese population are scant.Objective To analyze the association between RFM and the risk of CVD in middle-aged and elderly Chinese population(≥45 years old)using the data of China Health and Retirement Longitudinal Study(CHARLS).Methods This was a cross-sectional,longitudinal study using data available from CHARLS 2011-2018.In the cross-sectional study,12 867 middle-aged and elderly individuals aged 45 years or older were included.A total of 11 171 middle-aged and elderly individuals who were not diagnosed with CVD in the cross-sectional study in 2011 were included in the longitudinal study and followed up until 2018.Multivariate Logistic regression and restricted cubic splines(RCS)were used to analyze the cross-sectional association between RFM and CVD.Kaplan-Meier curves,multivariate Cox proportional hazards regression models,and RCS were used to analyze the longitudinal association between different baseline RFM levels in 2011 and the risk of incident CVD.Subgroup analysis was used to investigate the association between RFM and risk of CVD across subgroups,and sensitivity analysis was used to verify the stability of the model.Results Multivariate Logistic regression analysis showed that RFM was a risk factor for CVD(OR=1.03,95%CI=1.02-1.04,P<0.05).Compared with the Q1 group,Q2 group(OR=1.26,95%CI=1.07-1.49),Q3 group(OR=1.78,95%CI=1.47-2.16)and Q4 group(OR=1.81,95%CI=1.49-2.19)had a significantly higher risk of CVD(P<0.05).During the follow-up period,a total of 1 655(14.9%)individuals were diagnosed with CVD for the first time.Multivariate Cox regression analysis showed that RFM was a risk factor for CVD(HR=1.03,95%CI=1.02-1.04,P<0.05).Compared with Q1'group,the Q2'group(HR=1.31,95%CI=1.12-1.52),the Q3'group(HR=1.34,95%CI=1.12-1.61)and the Q4'group(HR=1.79,95%CI=1.49-2.14)had a significantly higher risk of new onset of CVD.Subgroup analysis showed that RFM had an interaction with marital status(P=0.022).The results of sensitivity analysis were consistent with the trends of the above results.Conclusion Higher levels of RFM are associated with an increased risk of CVD,suggesting that RFM may be of potential value in CVD prevention and treatment.关键词
心血管疾病/相对脂肪量/中老年人/中国健康与养老追踪调查/队列研究Key words
Cardiovascular disease/Relative fat mass/Middle-aged and elderly population/China Health and Retirement Longitudinal Study/Cohort study分类
医药卫生引用本文复制引用
陈慧龙,廖芸楚,刘育伟,孔政辉,黄兴辉,徐嘉辉,漆娜,王远平,梁文坚..相对脂肪量与中老年人群心血管疾病之间的关联:一项基于CHARLS的横断面与纵向研究[J].中国全科医学,2025,28(32):4047-4054,8.基金项目
国家自然科学基金青年科学基金(82405259) （82405259）
广东省基础与应用基础研究基金项目(2022A1515220151) （2022A1515220151）
广东省中医药局科研项目(20241015) （20241015）
