摘要
Abstract
Objective To investigate the effect of ultra picosecond combined with tranexamic acid in the treatment of patients with melasma and its impact on mMASI score.Methods One hundred and twenty patients with melasma from our hospital were selected from January 2023 to December 2024,and the patients were divided into two groups(n=60)based on the different treatment methods.The matched group received ultra picosecond laser therapy,while the observation group received a combination of tranexamic acid tablets.Compare the efficacy,mMASI score,skin barrier function,and facial image parameters between the two groups.Results The effective rate of the observation group was higher than that of the matched group,and the difference was statistically significant(P<0.05).Pretherapy,there was no statistically significant difference between the mMASI scores of the two groups compared to the matched group(P>0.05),and post-treatment,the mMASI scores of the observation group were lower than those of the matched group,with a statistically significant difference(P<0.05).Pretherapy,there was no statistically significant difference between the two groups compared to the percentage of discoloration,red areas and brown spots,skin red and green saturation,skin brightness,and skin blue and yellow saturation(P>0.05),and post-treatment,the observation group's discoloration,red areas and brown spots,percentage of red areas and brown spots,skin red and green saturation,skin blue and yellow saturation were lower than the matched group's,and skin brightness was higher than the matched group's,which was a statistically significant difference(P<0.05).There was no statistically significant difference in the incidence of edema,itching,hyperpigmentation and localized blisters compared to the two groups(P>0.05).Conclusions Ultra picosecond combined with tranexamic acid can promote the regression of skin lesions in patients with melasma,and improve facial images,with significant effects.关键词
超皮秒激光/氨甲环酸/黄褐斑/mMASI评分/面部图像参数Key words
ultra picosecond laser/tranexamic acid/chloasma/mMASI score/facial image parameters
