中国畜牧杂志2025，Vol.61Issue(9)：6-13,8.DOI:10.19556/j.0258-7033.20240813-03
IGF2与H19的表达和印记模式对哺乳动物胎盘发育的影响研究进展
Advances in the Effects of IGF2 and H19 Expression and Imprinting Patterns on Mammalian Placental Development
摘要
Abstract
Abnormal placental development or functional defect is one of important causes of early pregnancy failure in animals,which brings great economic loss to stockbreeding.However,the molecular mechanism is still unclear.Deeply revealing the mechanisms of early placenta formation and functional regulation in mammal is extremely important to ensure the success rate of pregnancy.As crucial imprinted genes,IGF2 and H19 play pivotal roles in the embryonic and placental development of mammals.High expression level of IGF2 is closely associated with rapid placental growth and differentiation,while H19 affects placental development by regulating the proliferation and differentiation of trophoblast cells.In addition,the interaction between IGF2 and H19,as well as their synergistic regulation with other factors,are also important factors affecting placental development.This article provides a detailed overview of the specific mechanisms of IGF2 and H19 during placental development in mammals,aiming to provide research ideas for scientifically and effectively predicting diseases related to placental maldevelopment in mammals,and thereby offering a theoretical reference for animal reproduction regulation and breeding.关键词
胎盘/滋养层细胞/IGF2/H19/母-胎关联Key words
Placenta/Trophoblast/IGF2/H19/Maternal-fetal association分类
生物科学引用本文复制引用
王乃未,林自力..IGF2与H19的表达和印记模式对哺乳动物胎盘发育的影响研究进展[J].中国畜牧杂志,2025,61(9):6-13,8.基金项目
都市农林特色教师队伍建设项目(11000023210200045626-XM001) （11000023210200045626-XM001）
北京农学院青年教师科研创新能力提升项目(QJKC2022023) （QJKC2022023）
