中国兽医杂志2025，Vol.61Issue(9)：28-35,8.DOI:10.20157/j.cnki.zgsyzz.2025.09.004
盐酸恩诺沙星颗粒治疗自然感染细菌性猪呼吸道疾病的剂量筛选
Dosage Screening of Enrofloxacin Hydrochloride Granules for Treating Natural Infection of Bacterial Swine Respiratory Diseases
摘要
Abstract
To determine the optimal and effective dosage of enrofloxacin hydrochloride granules for the treatment of naturally occurring bacterial swine respiratory disease(SRD),150 Du Changda Sanyuan hybrid pigs naturally infected with bacterial SRD were selected through clinical diagnosis,pathological necropsy,and bacterial isolation.The pigs were randomly divided into five groups:High-dose group(HDG),Medium-dose group(MDG),Low-dose group(LDG),Therapeutic control group(TFP),and Infection control group(ICG).The HDG,MDG,and LDG pigs were orally administered coated enrofloxacin hydrochloride granules at 10.0,7.5,and 5.0 mg/(kg·bw),respectively,mixed into feed once;for severe or chronic SRD cases,a second dose was given after 48 h.The TFP group received tiamulin fumarate premix at 87.5 g/1 000 kg feed for 10 consecutive days,while the ICG group received no medication.During the trial(day 0-24),daily monitoring of body weight and clinical signs was performed.On day 0 and day 24,body weight was recorded,and nasal swabs were collected for bacterial isolation and identification.Dead pigs during the trial were subjected to necropsy and histopathological examination.Cure rates for each treatment group were calculated after the trial.The results showed that all selected pigs exhibited symptoms such as anorexia,coughing,emaciation,and fever.Compared with the ICG group,pigs in all medicated groups had significantly increased body weight(P<0.05)and significantly reduced body temperature(P<0.05).Before treatment,nasal swabs from all groups yielded one or more SRD-associated pathogens,including Actinobacillus pleuropneumoniae,Pasteurella multocida,Streptococcus suis,and Glaesserella parasuis,with similar bacterial isolation rates among groups.After treatment,pathogen detection rates in nasal swabs were significantly reduced in all medicated groups(P<0.05),except for P.multocida in the TFP group(P>0.05).During the trial,two pigs died in the HDG and LDG groups,and four died in the ICG group,while no deaths occurred in the MDG or TFP groups.Necropsy of dead pigs revealed severe pneumonia,pulmonary interstitial edema and hemorrhage,inflammatory cell infiltration,and obvious compensatory alveolar expansion.Cure rates were 86.7%,83.3%,and 60.0%for the HDG,MDG,and LDG groups,respectively,and 86.7%for the TFP group.In conclusion,coated enrofloxacin hydrochloride granules administered at 7.5 mg/(kg·bw)mixed into feed,with a second dose after 48 h for severe or chronic respiratory disease cases,achieved the best therapeutic effect against naturally occurring bacterial SRD.Therefore,a dosage of 7.5 mg/(kg·bw)is recommended for clinical use,as it effectively treats bacterial SRD,reduces losses caused by the disease,lowers mortality,and saves labor and resources.关键词
盐酸恩诺沙星颗粒/猪/自然感染/细菌性呼吸道疾病/剂量筛选Key words
enrofloxacin hydrochloride granule/swine/natural infection/bacterial respiratory diseases/dosage screening分类
农业科技引用本文复制引用
周凯仁,周绪正,张继瑜,何源,董朕,吴灵玉,翟斌涛,王玮玮,程富胜,李冰,魏小娟..盐酸恩诺沙星颗粒治疗自然感染细菌性猪呼吸道疾病的剂量筛选[J].中国兽医杂志,2025,61(9):28-35,8.基金项目
国家重点研发计划项目(2022YFD1602201) （2022YFD1602201）
国家现代农业产业技术体系(CARS-37) （CARS-37）
甘肃省科技计划项目(23YFNA0001) （23YFNA0001）
甘肃舟曲县黑土猪产业质量标准体系建设项目(ZQJY-ZC-2023-048) （ZQJY-ZC-2023-048）
