中国医学科学院学报2025，Vol.47Issue(4)：519-526,8.DOI:10.3881/j.issn.1000-503X.16347
新型冠状病毒感染患者康复一年后血浆的非靶向代谢组学
Untargeted Metabolomics of Plasma From Coronavirus Disease 2019 Patients One Year After Recovery
摘要
Abstract
Objective To investigate the recovery of plasma metabolism in asymptomatic and mild pa-tients of coronavirus disease 2019(COVID-19)one year after recovery.Methods A total of 174 participants were recruited from the communities in Wuhan,including 80 healthy volunteers and the COVID-19 patients who had recovered for one year.According to the disease severity,the recovered COVID-19 patients were grouped as asymptomatic patients(n=80)and mild patients(n=14).The liquid chromatography mass spectrometry platform was employed to study the metabolomic characteristics of the plasma from all the participants.Results The plasma metabolites in asymptomatic patients and mild patients remained abnormal compared with those in healthy volunteers.Among the differential metabolites in asymptomatic patients and mild patients,some metabo-lites showed a downward trend only in mild patients,such as phosphatidylethanolamine[20∶3(5Z,8Z,11Z)/P-18∶0],sphingomyelin(d18∶1/24∶0),and cholesteryl(15∶0).The metabolic pathway invol-ving the differential metabolites in mild patients was mainly glycerophospholipid metabolism.Conclusions Even one year after recovery,the mild COVID-19 patients still exhibit metabolic abnormalities.Hence,these patients may experience an extended period of time for recovery.关键词
严重急性呼吸综合征冠状病毒2/新型冠状病毒感染/非靶向代谢组学/康复Key words
severe acute respiratory syndrome coronavirus 2/coronavirus disease 2019/untargeted metabolomics/recovery分类
医药卫生引用本文复制引用
张旭彤,杨晔宏,武乐,韩蓉,王翘楚,丁涛,柳江枫,杨俊涛..新型冠状病毒感染患者康复一年后血浆的非靶向代谢组学[J].中国医学科学院学报,2025,47(4):519-526,8.基金项目
中国医学科学院医学与健康科技创新工程(CIFMS2020-I2M-1-011) （CIFMS2020-I2M-1-011）
