中国医学科学院学报2025，Vol.47Issue(4)：550-556,7.DOI:10.3881/j.issn.1000-503X.16344
超声特征联合免疫组织化学对中年女性乳腺癌腋窝淋巴结转移的预测价值
Value of Ultrasonographic Features Combined With Immunohistochemistry in Predicting Axillary Lymph Node Metastasis in Middle-Aged Women With Breast Cancer
摘要
Abstract
Objective To investigate the value of ultrasonographic features combined with immunohis-tochemistry in predicting axillary lymph node metastasis in middle-aged women with breast cancer.Methods A retrospective analysis was conducted on 827 middle-aged female breast cancer patients who underwent surgical treatment at the Affiliated Hospital of Chengde Medical University from June 2017 to June 2023.Ultrasonographic and immunohistochemical information was collected,and the patients were randomly allocated into a training set(579 patients)and a validation set(248 patients).Univariate and multivariate Logistic regression analyses were performed to identify ultrasonographic and immunohistochemical risk factors associated with axillary lymph node metastasis in these patients,and a nomogram model was developed.Receiver operating characteristic curves and calibration curves were established to evaluate the performance of the nomogram model,and clinical decision curves were built to assess the clinical value of the model.Results The maximum diameter,morphology,boundary,calcification,and expression of human epidermal growth facor receptor 2 and Ki-67 in breast cancer lesions were identified as risk factors for predicting axillary lymph node metastasis in middle-aged women.The ar-eas under the curve of the nomogram model on the training and validation sets were 0.747(0.707-0.787)and 0.714(0.647-0.780),respectively.Calibration curves and clinical decision curves indicated good consistency and performance of the model.Conclusion The nomogram model constructed based on ultrasonographic features and immunohistochemistry of the primary breast cancer lesion demonstrates high value in predicting axillary lymph node metastasis in middle-aged women with breast cancer.关键词
乳腺癌/超声特征/免疫组织化学/淋巴结转移Key words
breast cancer/ultrasonographic features/immunohistochemistry/lymph node metastasis分类
医药卫生引用本文复制引用
常乾坤,吴文瑛,白春强,丁智超,王伟芳,刘铭函..超声特征联合免疫组织化学对中年女性乳腺癌腋窝淋巴结转移的预测价值[J].中国医学科学院学报,2025,47(4):550-556,7.基金项目
河北省医学科学研究课题计划(20231364) （20231364）
