中国医学科学院学报2025，Vol.47Issue(4)：567-574,8.DOI:10.3881/j.issn.1000-503X.16483
重度阻塞性睡眠呼吸暂停人群中循环miRNA-205与全身炎症状态的相关性分析
Correlation Analysis Between Circulating miRNA-205 and Systemic Inflammatory Status in Patients With Severe Obstructive Sleep Apnea
摘要
Abstract
Objective To investigate the correlations of circulating miRNA-205 expression with system-ic immune-inflammation index(SII)and systemic inflammation response index(SIRI)in patients with severe obstructive sleep apnea(OSA).Methods The patients who attended the Hypertension Center of the People's Hospital of Xinjiang Uygur Autonomous Region from January to June 2023 and underwent complete overnight poly-somnography were consecutively included in this study.Among them,30 patients had severe OSA,and 32 patients did not have OSA.Blood routine tests(white blood cells,neutrophils,monocytes,platelets,etc.)were performed and the expression of miRNA-205 was determined by quantitative reverse transcription PCR.Simple regression was adopted to analyze the correlations among miRNA-205,SII,SIRI,and OSA param-eters.The potential regulatory effects of miRNA-205 on OSA and inflammation indices were further evaluated.Results The patients with severe OSA showed lower expression of circulating miRNA-205[1.910(1.240,2.403)vs.3.650(2.148,5.109),z=-3.874,P＜0.001]and higher SIRI[1.090(0.775,1.573)vs.0.870(0.650,1.240),z=-2.031,P=0.041]and SII[555.200(451.780,936.350)vs.448.685(380.823,646.073),z=-2.029,P=0.042]than non-OSA patients.In the whole popula-tion,apnea-hypopnea index(AHI)showed a negative correlation with circulating miRNA-205(r=-0.391,P=0.002).Among severe OSA patients,each 1-unit increase in AHI was associated with a reduction of 0.030 in miRNA-205 and increases of 10.046 and 0.037 in SII and SIRI,respectively(SII:P=0.003;SIRI:P=0.037).Conversely,each 1-unit rise in miRNA-205 predicted a decrease of 121.093 in SII(β=-0.40,P=0.046).The low expression of miRNA-205 might have a negative moderating effect on elevated SII(β=-0.40,P=0.004).Conclusions Compared with the patients without OSA,those with severe OSA showed elevated SII and SIRI and down-regulated expression of miRNA-205.The low expression of miRNA-205 might have a negative moderating effect on the systemic inflammatory state associated with severe OSA.关键词
阻塞性睡眠呼吸暂停/miRNA/炎症指数Key words
obstructive sleep apnea/miRNA/inflammation index分类
医药卫生引用本文复制引用
苏比江·吐尔逊,姚晓光,吴婷,木拉力别克·黑扎提,布阿依仙木·艾麦提..重度阻塞性睡眠呼吸暂停人群中循环miRNA-205与全身炎症状态的相关性分析[J].中国医学科学院学报,2025,47(4):567-574,8.基金项目
新疆维吾尔自治区重点实验室开放课题(2022D04024) （2022D04024）
