中国普通外科杂志2025，Vol.34Issue(7)：1340-1346,7.DOI:10.7659/j.issn.1005-6947.250304
肝细胞癌转化治疗存在的难点与挑战
Challenges and difficulties in conversion therapy for hepatocellular carcinoma
摘要
Abstract
Hepatocellular carcinoma(HCC)is a malignant tumor that poses a serious threat to human health.The burden of HCC in China is substantial,and most patients are diagnosed at intermediate or advanced stages,with a 5-year survival rate of only 14.4%.Conversion therapy aims to transform initially unresectable HCC into resectable disease to improve patient prognosis,but it faces numerous challenges in clinical practice.First,Chinese HCC patients differ significantly from those in North America,Japan,and other regions in terms of tumor characteristics and etiology,necessitating exploration of localized conversion therapy strategies suitable for Chinese patients.Second,the target population for conversion therapy remains unclear,with controversies over the distinction and patient selection between neoadjuvant and conversion therapies,and a lack of high-level evidence to guide practice.Third,the selection of conversion therapy regimens is challenging,as there are many drug options but no unified standards,and the choice and timing of combined local therapies are difficult to determine,requiring further clinical validation.Moreover,post-conversion treatment strategies are contentious;it remains unclear whether patients achieving radiological or clinical complete response should undergo surgery,preoperative prediction of complete pathological response is difficult,and postoperative sequential strategies and regimen selection are not well defined.Future efforts should focus on identifying biomarkers,conducting multicenter,large-sample,prospective clinical trials,and standardizing treatment protocols and processes to improve the prognosis and quality of life of HCC patients.关键词
癌,肝细胞/转化治疗/肿瘤治疗方案Key words
Carcinoma,Hepatocellular/Conversion Therapy/Antineoplastic Protocols分类
医药卫生引用本文复制引用
李广涛,宋天强..肝细胞癌转化治疗存在的难点与挑战[J].中国普通外科杂志,2025,34(7):1340-1346,7.基金项目
天津市教育委员会科研计划基金资助项目(2022KJ227). （2022KJ227）
