中国医学创新2025，Vol.22Issue(24)：160-163,4.DOI:10.3969/j.issn.1674-4985.2025.24.037
住院患者CRE检出情况及其阳性危险因素分析
Analysis of CRE Detection and Positive Risk Factors in Hospitalized Patients
摘要
Abstract
Objective:To investigate the associated risk factors and clinical characteristics of carbapenem-resistant Enterobacteriaceae(CRE)detection among hospitalized patients,and to analyze the epidemiological distribution of carbapenemase types in CRE strains,providing evidence for hospital infection control and rational use of antibiotics.Method:A retrospective survey was conducted on 214 inpatients admitted to Ji'an Central People's Hospital from January 2022 to May 2024.The patients were stratified into control group(n=139)and study group(n=75)based on the detection status of CRE during hospitalization.Bacterial identification and antimicrobial susceptibility testing were performed using the DL-96A system.The type of carbapenemase produced by the strain was detected by the carbapenemase inhibitor enhancement test PBA-EDTA method and PCR.Collect patients'clinical data and perform univariate and multivariate logistic regression analyses to identify independent risk factors for CRE detection.Result:Among the 75 patients with CRE detected,KPC-producing strains were predominant[50.67%(38/75)],followed by NDM-producing strains[28.00%(21/75)]and OXA-48-producing strains[8.00%(6/75)],with co-expression of multiple carbapenemase enzymes observed in some isolates.Univariate and multivariate analyses revealed that hospitalization for≥14 d,ICU admission,use of third-generation or higher cephalosporins,carbapenems,quinolones,mechanical ventilation,central venous catheters placement,and indwelling urinary catheters were all independent risk factors for CRE detection(P<0.05).Conclusion:The primary resistance mechanisms of CRE among hospitalized patients are the production of KPC and NDM carbapenemases.Extended hospitalization,ICU treatment,broad-spectrum antibiotic use,and invasive procedures are significant risk factors for CRE detection.Strengthening screening in high-risk populations,standardizing antibiotic use,and managing invasive procedures are crucial for reducing the risk of CRE infections.关键词
碳青霉烯类耐药肠杆菌/住院患者/碳青霉烯酶/抗菌药物管理Key words
Carbapenem-resistant Enterobacteriaceae/Hospitalized patients/Carbapenemase/Antimicrobial stewardship引用本文复制引用
唐晶,陈吉媛,杨来喜,高强..住院患者CRE检出情况及其阳性危险因素分析[J].中国医学创新,2025,22(24):160-163,4.基金项目
吉安市科学技术局项目(20244-049179) （20244-049179）
