摘要
Abstract
Objective:To explore the clinical effect of pentoxifylline combined with ozagrel sodium in the treatment of acute cerebral infarction(ACI).Methods:A total of 96 ACI patients admitted to a hospital from June 2022 to June 2024 were selected and divided into the control group and the observation group by random number table method,with 48 patients in each group.Both groups received conventional treatment.The control group was given ozagrel sodium for injection on the basis of conventional treatment,and the observation group was additionally given pentoxifylline for injection on the basis of the treatment of the control group.Both groups were treated continuously for 14 days and followed up for 3 months.Neurological function[National Institutes of Health Stroke Scale(NIHSS)score],hemorheological indexes(plasma viscosity,whole blood high-shear viscosity,whole blood low-shear viscosity),inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),high-sensitivity C reactive protein(hs-CRP)],oxidative stress indexes[malondialdehyde(MDA),superoxide dismutase(SOD)]and adverse reactions were compared between the two groups.Results:After 14 days of treatment,NIHSS scores in both groups were lower than those before treatment,at 3 months of follow-up,NIHSS scores in both groups were lower than those after 14 days of treatment,and the observation group was lower than the control group(P<0.05).At 3 months of follow-up,plasma viscosity,whole blood high-shear viscosity and whole blood low-shear viscosity were decreased in both groups,with lower levels in the observation group(P<0.05).After 14 days of treatment,levels of IL-6,TNF-α,hs-CRP and MDA were decreased in both groups,with lower levels in the observation group(P<0.05).SOD level was increased in both groups,with a higher level in the observation group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Pentoxifylline combined with ozagrel sodium can significantly improve hemorheology in ACI patients,reduce oxidative stress levels,alleviate neurological deficits,and does not increase the risk of adverse reactions.关键词
己酮可可碱/奥扎格雷钠/急性脑梗死/神经功能缺损/不良反应Key words
pentoxifylline/ozagrel sodium/acute cerebral infarction/neurological deficits/adverse reactions分类
医药卫生
