中国当代儿科杂志2025，Vol.27Issue(9)：1089-1097,9.DOI:10.7499/j.issn.1008-8830.2502097
注意缺陷多动障碍儿童各类精神障碍的多基因遗传风险与临床症状及认知功能的相关性分析
Relationship between polygenic risk scores for various psychiatric disorders and clinical and neuropsychological characteristics in children with attention-deficit/hyperactivity disorder
摘要
Abstract
Objective To investigate the relationship between the polygenic risks for various psychiatric disorders and clinical and neuropsychological characteristics in children with attention-deficit/hyperactivity disorder(ADHD).Methods Using a cross-sectional design,285 children with ADHD and 107 healthy controls were assessed using the Child Behavior Checklist,the Behavior Rating Inventory of Executive Function for parents,the Wechsler Intelligence Scale for Children,Fourth Edition,and the Cambridge Neuropsychological Test Automated Battery.Blood samples were collected for genetic data.Polygenic risk scores(PRSs)for various psychiatric disorders were calculated using the PRSice-2 software.Results Compared with the healthy controls,the children with ADHD displayed significantly higher PRSs for ADHD,major depressive disorder,anxiety disorder,and obsessive-compulsive disorder(P＜0.05).In terms of daily-life executive function,ADHD-related PRS was significantly correlated with the working memory factor;panic disorder-related PRS was significantly correlated with the initiation factor;bipolar disorder-related PRS was significantly correlated with the shift factor;schizophrenia-related PRS was significantly correlated with the inhibition,emotional control,initiation,working memory,planning,organization,and monitoring factors(P＜0.05).The PRS related to anxiety disorders was negatively correlated with total IQ and processing speed index(P＜0.05).The PRS related to obsessive-compulsive disorder was negatively correlated with the processing speed index and positively correlated with the stop-signal reaction time index of the stop-signal task(P＜0.05).Conclusions PRSs for various psychiatric disorders are closely correlated with the behavioral and cognitive characteristics in children with ADHD,which provides more insights into the heterogeneity of ADHD.关键词
注意缺陷多动障碍/多基因遗传风险/精神障碍/行为/认知功能/儿童Key words
Attention-deficit/hyperactivity disorder,Polygenic risk score/Psychiatric disorder/Behavior/Cognitive function/Child引用本文复制引用
吴赵敏,王玉凤,李颖,杨斌让,王鹏,董超,操小兰,胡兰芳,寇聪,江家靖,张琳琳,杨莉..注意缺陷多动障碍儿童各类精神障碍的多基因遗传风险与临床症状及认知功能的相关性分析[J].中国当代儿科杂志,2025,27(9):1089-1097,9.基金项目
深圳市医疗卫生三名工程项目(SZSM201612036) （SZSM201612036）
深圳市科技计划资助(RCYX20221008092849069) （RCYX20221008092849069）
广东省高水平医院建设专项经费. （）
