中国癌症防治杂志2025，Vol.17Issue(4)：401-407,7.DOI:10.3969/j.issn.1674-5671.2025.04.01
核酸适配体在癌症诊断及治疗应用中的研究进展
Research progress on the application of aptamers in cancer diagnosis and therapy
摘要
Abstract
Aptamers are single-stranded DNA or RNA molecules obtained through the systematic evolution of ligands by exponential enrichment(SELEX),exhibit high specificity in recognizing and binding to target molecules,including metal ions,small molecules,proteins,and cells.Aptamers offer several advantages,such as low molecular weight,a broad target range,ease of synthesis,low immunogenicity,and high stability,thereby demonstrating significant potential in cancer research.Currently,aptamers are widely used in biosensing technologies,including electrochemical,colorimetric,fluorescent,and chemiluminescent sensors,facilitating the highly specific detection of tumor biomarkers and enhancing the sensitivity of diagnostic tools for cancer detection.Furthermore,aptamers present novel strategies for cancer therapy through mechanisms such as targeted drug delivery and immune checkpoint blockade.This article provides a systematic review of the fundamental characteristics of aptamers and their advancements in biosensing technology and cancer therapy applications.关键词
核酸适配体/传感技术/癌症/检测/诊断/治疗Key words
Aptamer/Sensing technology/Cancer/Detection/Diagnosis/Therapy分类
医药卫生引用本文复制引用
陆子琛,赵日欣,李响,巩海将,王清雨,盖世丽,丁鹤..核酸适配体在癌症诊断及治疗应用中的研究进展[J].中国癌症防治杂志,2025,17(4):401-407,7.基金项目
国家自然科学基金面上项目(52272144) （52272144）
