摘要
Abstract
Objective:To investigate the clinical efficacy and safety of the triple therapy(Budesonide+Cetirizine+Montelukast Sodium)in the treatment of cough variant asthma in children,and to evaluate its effect on improving lung ventilation function,immune function,and inhibiting airway structural changes in children.Method:A total of 120 children with cough variant asthma admitted to the Pediatrics Department of Suqian First People's Hospital from June 2022 to June 2024 were selected as the research subjects.They were divided into the control group and the experimental group by random number table method,with 60 cases in each group.The control group was treated with Budesonide,and the experimental group was treated with Budesonide+Cetirizine+Montelukast Sodium.The changes of pulmonary ventilation function indicators[forced expiratory flow at 25%of FVC exhaled(FEF25%),forced expiratory flow at 50%of FVC exhaled(FEF50%),forced expiratory flow at 75%of FVC exhaled(FEF75%)],immune function indicators(IgA,IgG),and airway remodeling mediators[human cartilage glycoprotein-39(HCgp-39),osteopontin(OPN)]between the two groups were observed,and the therapeutic effects and adverse reactions of the two groups were evaluated.Result:After 8 weeks of treatment,the levels of FEF25%,FEF50%,FEF75%,IgA and IgG in the experimental group were all higher than those in the control group,the differences were statistically significant(P<0.05).The total control rate of the experimental group was higher than that of the control group,the difference was statistically significant(P<0.05).After 8 weeks of treatment,the levels of HCgp-39 and OPN in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Children with cough variant asthma who inhale Budesonide through nebulization and take Cetirizine and Montelulast Sodium orally can regulate immune function,inhibit airway structural changes,promote the recovery of pulmonary ventilation function,improve the condition of children,and the triple therapy has high safety.关键词
儿童咳嗽变异性哮喘/布地奈德/西替利嗪/孟鲁司特钠Key words
Children with cough variant asthma/Budesonide/Cetirizine/Montelulast Sodium
