中国癌症防治杂志2025，Vol.17Issue(4)：440-445,6.DOI:10.3969/j.issn.1674-5671.2025.04.07
育龄期女性HER2低表达乳腺癌三级淋巴结构的临床病理意义
Clinicopathological implications of tertiary lymphoid structures in HER2-low breast cancer in women of reproductive age
摘要
Abstract
Objective To investigate the association between tertiary lymphoid structures(TLSs)and clinicopathological param-eters,biomarkers,and prognosis in human epidermal growth factor receptor 2(HER2)-low breast cancer among women of reproductive age.Methods Clinical and prognostic data were collected from female patients with HER2-low breast cancer,aged 15 to 49 years,treated at Guangxi Medical University Cancer Hospital between January 2019 and December 2022.Whole slide image(WSI)analysis was performed to evaluate the presence and maturity of TLSs in HER2-low breast cancer,and their correlation with disease-free survival(DFS)was analyzed.Results The analysis included 225 patients,with a median age of 44 years(range:28-49 years),and TLSs were detected in 36.0％(81/225)of cases.The presence and maturity of TLSs were significantly associated with tumor histological grade,associated ductal carcinoma in situ(DCIS),expression of estrogen receptor(ER),progesterone receptor(PR),Ki-67 and molecular subtypes(all P＜0.05).Multivariate Cox regression analyses indicated that the presence and maturity of TLSs were independent predictors of decreased DFS(all P＜0.05).Conclusions The presence and maturity of TLSs are independently associated with poor prognosis in reproductive-aged women diagnosed with HER2-low breast cancer.This suggest that TLSs may hold potential as prognostic biomarkers and targets for immunotherapy.关键词
乳腺癌/三级淋巴结构/人表皮生长因子受体-2/育龄期/肿瘤免疫微环境Key words
Breast cancer/Tertiary lymphoid structures/Human epidermal growth factor receptor 2/Reproductive age/Tumor immune microenvironment分类
医药卫生引用本文复制引用
张志兴,李春君,张冬冬,陈肖瑜,黄玉珍,曾丽霞..育龄期女性HER2低表达乳腺癌三级淋巴结构的临床病理意义[J].中国癌症防治杂志,2025,17(4):440-445,6.基金项目
广西壮族自治区科技厅项目(2025GXNSFAA069120) （2025GXNSFAA069120）
广西壮族自治区卫生健康委员会西医类别自筹经费科研课题项目(Z-A2024712 （）
Z-A20220742) （）
