中国癌症防治杂志2025，Vol.17Issue(4)：452-457,6.DOI:10.3969/j.issn.1674-5671.2025.04.09
肿瘤患者经中心静脉输注优替德隆发生导管相关皮肤不良反应的现状及其影响因素分析
Analysis of the present status of catheter-related dermatological adverse reactions in cancer patients undergoing central venous infusion of Utidelone and its influencing factors
杨柳娜 1郑紫薇 1林宇萍 1杨丝雨 1朱瑞云 1黄雯薏 1石思梅1
作者信息
- 1. 510080 广州 中山大学肿瘤防治中心内科
- 折叠
摘要
Abstract
Objective To investigate the incidence of catheter-related dermatological adverse reactions in cancer patients undergoing central venous infusion of Utidelone and the influencing factors.Methods A retrospective analysis was conducted on clinical data from cancer patients who received Utidelone infusions via peripherally inserted central catheter(PICC)or totally implanted access port(TIAP)at Sun Yat-sen University Cancer Center between March 2021 and March 2024.To investigate the factors influencing cathete-related dermatological adverse reactions,univariable analysis and binary Logistic regression were employed.Results Among the 205 patients included in study,40(19.5％)experienced catheter-related dermatological adverse reactions,29(72.5％)of these cases resulting in the unplanned removal of the infusion device.Univariable analysis identified a significant association between the occurrence of catheter-related dermatological adverse reactions and factors such as alcohol consumption history,total cycles of Utidelone treatment,infusion method,type of catheter,and catheter insertion vein(all P＜0.05).Further Logistic regression analysis identified several risk factors for catheter-related dermatological adverse reactions,including the alcohol consumption history(OR=8.112,95％CI:1.616-40.728),the more total cycles of Utidelone treatment(OR=1.212,95％CI:1.043-1.409),and catheter insertion via the internal jugular vein for TIAP(OR=4.816,95％CI:1.136-20.425)or brachial vein for PICC(OR=34.171,95％CI:2.136-546.573).Conclusions The incidence of catheter-related dermatological adverse reactions is relatively high in patients receiving Utidelone via central venous infusion,potentially influenced by alcohol consumption history,the total cycles of treatment,and the choice of insertion vein.It is recommended that healthcare providers enhance monitoring of skin around the catheter site and develop preventive strategies targeting these influencing factors to reduce the incidence of adverse reactions.关键词
肿瘤/中心静脉/优替德隆/导管相关皮肤不良反应/影响因素Key words
Cancer/Central venous/Utidelone/Catheter-related dermatological adverse reactions/Influencing factors分类
医药卫生引用本文复制引用
杨柳娜,郑紫薇,林宇萍,杨丝雨,朱瑞云,黄雯薏,石思梅..肿瘤患者经中心静脉输注优替德隆发生导管相关皮肤不良反应的现状及其影响因素分析[J].中国癌症防治杂志,2025,17(4):452-457,6.
