安徽医科大学学报2025，Vol.60Issue(8)：1418-1422,1431,6.DOI:10.19405/j.cnki.issn1000-1492.2025.08.008
钛纳米管负载地塞米松羟基磷灰石复合涂层的实验研究
The experimental study of titanium nanotube loaded dexamethasone hydroxyapatite composite coating
摘要
Abstract
Objective To explore the biocompatibility of hydroxyapatite and dexamethasone composite coatings on the surface of TiO2 nanotubes.Methods A composite coating was constructed by loading hydroxyapatite and dexa-methasone on the surface of titanium nanotubes.Field emission scanning electron microscopy,atomic force micros-copy,and contact angle measurement instrument was used to observe the characteristics of sample substrates,and in vitro biological evaluation was conducted to evaluate the effect of the coating on the adhesion and proliferation of hu-man skull osteoblasts.Results The microstructure,three-dimensional morphology and hydrophilic properties of the modified composite coating had changed.After cytological examination,it could significantly promote the adhesion and proliferation of osteoblasts.Conclusion By simulating the immersion of body fluids and the method of adding dropwise loads,the titanium nanotube-hydroxyapatite-dexamethasone composite coating is successfully constructed,which has good biocompatibility.关键词
钛纳米管/羟基磷灰石/地塞米松/复合涂层/成骨细胞Key words
TiO2 nanotubes/hydroxyapatie/dexamethasone/composite coating/osteoblasts分类
医药卫生引用本文复制引用
高啟坤,吴明月..钛纳米管负载地塞米松羟基磷灰石复合涂层的实验研究[J].安徽医科大学学报,2025,60(8):1418-1422,1431,6.基金项目
国家自然科学基金项目(编号:81170993) （编号:81170993）
安徽省高校科研项目(编号:2024AH050683) National Natural Science Foundation of China(No.81170993) （编号:2024AH050683）
Natural Science Research Pro-ject of Anhui Educational Committee(No.2024AH050683) （No.2024AH050683）
