北京中医药2025，Vol.44Issue(8)：967-970,4.DOI:10.16025/j.1674-1307.2025.08.004
快速进展型特发性炎症性肌病继发间质性肺疾病的中西医临床特征分析
TCM and Western medicine clinical characteristics of rapidly progressing idiopathic inflammatory myopathy with interstitial lung disease
摘要
Abstract
Objective To analyze the clinical characteristics of rapidly progressing idiopathic inflammatory myopathy associated with interstitial lung disease(IIM-ILD)from both traditional Chinese medicine(TCM)and Western medicine perspectives.Methods This retrospective case-control study included 36 patients diagnosed with rapidly progressing IIM-ILD at Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,from January 2016 to January 2023.Data collected and analyzed included demographic information,disease course,clinical manifestations or complications,laboratory test results,imaging findings,TCM syndrome characteristics,and short-term prognosis.Stable IIM-ILD patients were selected as the control group,matched by age and sex in a 1:2 ratio.The TCM syndrome characteristics of rapidly progressing IIM-ILD were summarized,and risk factors for poor short-term prognosis were evaluated.Results In TCM syndrome differentiation,the excess syndromes of rapidly progressing IIM-ILD were mainly characterized by dampness-heat accumulation in the lungs,dampness-heat retention,disturbance of nutrient blood,and obstruction of lung qi.Among deficiency syndromes,asthma collapse accounted for the highest proportion.Positive anti-MDA5 antibody(P=0.008)was identified as a risk factor for poor short-term prognosis in patients with rapidly progressing IIM-ILD.Conclusion Rapidly progressing IIM-ILD is characterized by a lower oxygenation index and higher ferritin levels.Positive anti-MDA5 antibody is a risk factor for poor short-term prognosis.In TCM syndrome differentiation of rapidly progressing IIM-ILD,dampness-heat accumulation in the lungs is the predominant excess syndrome,while asthma collapse is the most frequent deficiency syndrome.关键词
特发性炎症性肌病/间质性肺疾病/辨证论治/临床特征Key words
idiopathic inflammatory myopathy/interstitial lung disease/syndrome differentiation and treatment/clinical characteristics引用本文复制引用
张宗学,王玉光,郭丽娅,刘锡曈,王亚南,孟广松..快速进展型特发性炎症性肌病继发间质性肺疾病的中西医临床特征分析[J].北京中医药,2025,44(8):967-970,4.基金项目
国家中医药管理局科技司中医药循证能力建设项目 （）
高层次公共卫生技术人才培养建设项目计划(学科带头人-01-16) （学科带头人-01-16）
