北京中医药2025，Vol.44Issue(8)：986-991,6.DOI:10.16025/j.1674-1307.2025.08.008
儿童重症肺炎支原体肺炎中医证型与临床特征的相关性研究
Correlation of Traditional chinese medicine syndromes with clinical phenotypes in pediatric severe Mycoplasma pneumoniae Pneumonia
摘要
Abstract
Objective To explore the relationship between traditional Chinese medicine(TCM)syndrome types and the clinical characteristics of severe Mycoplasma pneumoniae pneumonia(SMPP)in children.Methods A total of 408 children with SMPP who were hospitalized in the Department of Traditional Chinese Medicine at Beijing Children's Hospital,affiliated with Capital Medical University,from September 2019 to November 2023,were included in the study.TCM syndrome typing was conducted,and the characteristics of clinical manifestations and indicators of each syndrome type were observed.Results The most common TCM syndrome in children with SMPP was phlegm-heat obstructing lung syndrome,followed by toxin-heat obstructing lung syndrome,with high fever being the predominant symptom.Healthy qi deficiency and pathogen lingering syndrome and lung and spleen qi deficiency syndrome had a longer duration of illness,with moderate fever being more common.Toxin-heat obstructing lung syndrome was associated with mixed infections and pulmonary atelectasis,and had the highest incidence of necrotizing pneumonia(NP).Pleural effusions were most common in phlegm-heat obstructing lung syndrome,which was also associated with a higher incidence of obstructive bronchitis and plastic bronchitis(PB).Obstructive bronchitis was most commonly seen in healthy qi deficiency and pathogen lingering syndrome.Myocardial damage and hepatic damage were more prevalent in toxin-heat obstructing lung syndrome and phlegm-heat obstructing lung syndrome.Infectious reaction rash was mainly concentrated in toxin-heat obstructing lung syndrome.The index values of ferritin,absolute neutrophil count,ALT,AST,CRP,LDH,α-HBDH,and D-D showed a significant gradient:toxin-heat obstructing lung syndrome>phlegm-heat obstructing lung syndrome>healthy qi deficiency and pathogen lingering syndrome>lung and spleen qi deficiency syndrome(P<0.05).Conclusion There is a certain correlation between TCM syndrome types and the clinical features of SMPP.Toxin-heat obstructing lung syndrome presents the most severe clinical manifestations,characterized by significantly elevated myocardial enzymes,liver enzymes,and inflammatory markers,requiring vigilance for the occurrence of pulmonary atelectasis and NP.Toxin-heat obstructing lung syndrome,phlegm-heat obstructing lung syndrome,and healthy qi deficiency and pathogen lingering syndrome are often associated with a hypercoagulable state,which is correlated with elevated D-D levels.Phlegm-heat obstructing lung syndrome is associated with the formation of PB.关键词
儿童/重症肺炎支原体肺炎/中医证型/临床特征Key words
children/severe Mycoplasma pneumoniae pneumonia/traditional Chinese medicine syndrome type/clinical features引用本文复制引用
纪丰烨,朱中一,周兆馨,张金,王玲,潘岩,杨燕..儿童重症肺炎支原体肺炎中医证型与临床特征的相关性研究[J].北京中医药,2025,44(8):986-991,6.基金项目
首都卫生发展科研专项(首发2024-2-2096) （首发2024-2-2096）
第六批北京市级中医药专家学术经验继承工作项目(京中医科字[2021]160号) （京中医科字[2021]160号）
北京市中医妇幼名医传承工作室建设项目(2022-FYGZS-26) （2022-FYGZS-26）
