滨州医学院学报2025，Vol.48Issue(4)：380-383,4.DOI:10.19739/j.cnki.issn1001-9510.2025.04.009
HA380血液灌流在脓毒症急性肾损伤患者中的临床疗效
Observation of the Therapeutic Efficacy of HA380 Blood Perfusion in Patients with Sepsis-Induced Acute Kidney Injury
摘要
Abstract
Objective To investigate the application of continuous static intravenous hemofiltration(CVVH)combined with HA380 hemoperfusion in septic acute renal injury.Methods A total of 60 cases of septic acute kidney injury admitted to the People's Critical Care Department of Linyi City from January 2022 to December 2023 were selected and randomly divided into control group and experimental group,with 30 cases in each group.Patients in the control group received conventional treatment and CVVH treatment,and patients in the test group were treated with HA380 hemoperfusion based on the control group,and the changes in APACHE Ⅱ score,SOFA score,ICU stay,total hospital stay,inflammatory factors,renal function and other indica-tors were observed and compared in the two groups.Results There were no significant differences in baseline characteristics be-tween the two groups.Patients in the experimental group demonstrated significantly lower APACHE Ⅱ and SOFA scores at 72 hours post-treatment compared to the control group(P＜0.05).The experimental group also showed shorter ICU stays and total hospital stays than the control group(P＜0.05).Notably,the experimental group exhibited significantly lower creatinine levels and higher urine output at 72 hours after treatment,with both parameters showing statistically significant differences(P＜0.05).Conclusion HA380 hemoperfusion has a good therapeutic effect on septic acute kidney injury,which can significantly improve the critical degree of patients,reduce the level of inflammatory factors,and improve renal function.关键词
连续性静-静脉血液滤过/HA380血液灌流/脓毒症急性肾损伤/疗效观察Key words
continuous venovenous hemofiltration/HA380 blood perfusion/sepsis-induced acute kidney injury/therapeutic efficacy observation分类
医药卫生引用本文复制引用
李振明,刘瑞金,薄文迪,郑娟娟,张建国,陈晓娟..HA380血液灌流在脓毒症急性肾损伤患者中的临床疗效[J].滨州医学院学报,2025,48(4):380-383,4.基金项目
中国人体健康科技促进会科研专项资金项目(JKH2023001) （JKH2023001）
