成都大学学报（自然科学版）2025，Vol.44Issue(3)：239-245,7.DOI:10.3969/j.issn.1004-5422.2025.03.003
基于物理指纹图谱的竹节参配方颗粒成型工艺研究
Research on Forming Process of Panax Japonicus Formula Granules Based on Physical Fingerprint Spectrum
摘要
Abstract
Based on physical fingerprint spectrum,the forming process of the Panax japonicus formula granules is investigated.A single-factor experiment is conducted to investigate the types of diluents by u-sing the hygroscopicity(H)as an indicator,and the types and amounts of wetting agents are investigated by using the forming rate,Carr's index(IC),angle of repose(α),and H as comprehensive indicators.The Box-Behnken response surface methodology is employed to optimize the forming process,with bulkiness,fluidity,stability,uniformity,and compressibility serving as the primary indicators for the physical finger-print spectrum of Panax japonicus formula granules.The secondary indicators include loose density(Da),tapped density(Dc),α,Hausner ratio(IH),loss on drying(HR),H,relative uniformity index(Iθ),in-ter-particle porosity(Ie),and IC.Process validation of the forming process is conducted based on the aforementioned secondary indicators,and a physical fingerprint spectrum is established for similarity eval-uation.The results show that the optimal diluent is microcrystalline cellulose,with a usage ratio of diluent from 50％to 100％(the percentage of raw materials).The wetting agent is 75％～85％ethanol,account-ing for 20～25 mL/100 g(the total raw and auxiliary materials).The similarity evaluation of the physical fingerprint spectrum reveals that the Panax japonicus formula granules prepared according to the above process exhibits stable properties with a similarity above 0.90.关键词
竹节参/配方颗粒/成型工艺/物理指纹图谱Key words
Panax japonicus/formula granules/forming process/physical fingerprint spectrum分类
医药卫生引用本文复制引用
刘钱,刘晓凤,戴静,刘博文,任华忠,伍利华..基于物理指纹图谱的竹节参配方颗粒成型工艺研究[J].成都大学学报（自然科学版）,2025,44(3):239-245,7.基金项目
四川省抗病毒中药产业化工程技术研究中心开放课题(KT2024-005、KF202406) （KT2024-005、KF202406）
四川省药物制剂及装备工程技术研究中心开放课题(ERCPEF2305、ERCPEF2405) （ERCPEF2305、ERCPEF2405）
乐山市科技局自然科学项目(2SZD015) （2SZD015）
