动物医学进展2025，Vol.46Issue(11)：55-61,7.
山奈酚对耐头孢曲松大肠埃希氏菌的协同抑菌作用
Synergistic Inhibitory Effect of Kaempferol on Ceftriaxone-resistant Escherichia coli
摘要
Abstract
To investigate the effects of kaempferol with ceftriaxone on ceftriaxone-resistant Escherichia co-li,six strains of clinically isolated ceftriaxone-resistant E.coli were utilized.The synergistic bacteriostatic effect of kaempferol with these resistant strains was examined.Results indicated that the combination of kaempferol and ceftriaxone exhibited synergistic effects against ceftriaxone-resistant E.coli(FICI＜0.5).This combination effectively inhibited the growth of the resistant bacteria,and continuous treatment with kaempferol led to a reduction in resistance development among these strains.Furthermore,treatment with kaempferol alongside ceftriaxone significantly enhanced membrane permeability and compromised mem-brane integrity(P＜0.01),resulting in varying degrees of damage to both the cell membrane and wall,as well as leakage of cellular contents.These findings suggested that the co-administration of kaempferol and ceftriaxone exerted the synergistic bacteriostatic effect by impairing cell membrane permeability and integ-rity in ceftriaxone-resistant E.coli.关键词
耐头孢曲松大肠埃希氏菌/山奈酚/协同作用/细胞膜通透性Key words
Ceftriaxone-resistant E.coli/Kaempferol/Synergistic effect/Membrane permeability引用本文复制引用
李鹏程,张为民,张雯,肖兴兰,邵倩,朱磊鑫,丁栋昭,朱欣茹,刘玉杰,杨奇..山奈酚对耐头孢曲松大肠埃希氏菌的协同抑菌作用[J].动物医学进展,2025,46(11):55-61,7.基金项目
宁夏回族自治区畜产品安全与品质监控创新团队(2022BSB03108) （2022BSB03108）
西北农林科技大学大学生创新创业训练计划项目(X202410712329) （X202410712329）
