中国耳鼻咽喉头颈外科2025，Vol.32Issue(8)：486-491,6.DOI:10.16066/j.1672-7002.2025.08.003
骨膜蛋白在慢性鼻窦炎中的表达及临床意义
Expression and clinical significance of Periostin in chronic rhinosinusitis
摘要
Abstract
OBJECTIVE To investigate the expression and clinical significance of Periostin in tissues of patients with chronic rhinosinusitis(CRS).METHODS Real-time quantitative PCR and immunohistochemistry were used to detect periostin expression in eosinophilic CRS with nasal polyps(ECRSwNP),non-eosinophilic CRS with nasal polyps(non-ECRSwNP),CRS without nasal polyps(CRSsNP),and control tissues.Correlations between periostin levels and blood eosinophil percentage(Eos%),Lund-Mackay score,modified endoscopic score,and Japanese epidemiological survey of refractory eosinophilic chronic rhinosinusitis(JESREC)score were analyzed.Additionally,changes in SNOT-22 and VAS scores were compared at different preoperative and postoperative times.The predictive value of periostin for ECRSwNP was evaluated using receiver operating characteristic(ROC)curve analysis.RESULTS Periostin expression was detected in all groups(ECRSwNP,non-ECRSwNP,CRSsNP,and controls),with predominant localization in the basement membrane and mucosal subepithelial lamina propria.Significantly elevated periostin levels were detected in the ECRSwNP group compared to the other three groups(P<0.001).Furthermore,Periostin mRNA expression showed significant positive correlations with blood Eos%,JESREC score,and Lund-Mackay score.SNOT-22 and VAS scores were significantly elevated in the ECRSwNP group at preoperative evaluation and 9 months postoperatively(P<0.001).ROC curve analysis demonstrated that periostin had a substantial predictive value for ECRSwNP(AUC=0.957).CONCLUSION Periostin plays a crucial role in the pathogenesis of chronic rhinosinusitis,contributing to the diagnosis,severity assessment,and prognosis evaluation of ECRSwNP,while offering potential therapeutic targets for CRS management.关键词
鼻窦炎/鼻息肉/嗜酸细胞/骨膜蛋白/疾病严重程度Key words
Sinusitis/Nasal Polyps/Eosinophils/Periostin/disease severity引用本文复制引用
刘龙燕,石元贞,厚媛,丁文娟,李勇,刘增平,段世宏..骨膜蛋白在慢性鼻窦炎中的表达及临床意义[J].中国耳鼻咽喉头颈外科,2025,32(8):486-491,6.基金项目
甘肃省自然科学基金项目(24JRRA372) （24JRRA372）
兰州市科技计划项目(2023-2-81) （2023-2-81）
