中国耳鼻咽喉头颈外科2025，Vol.32Issue(8)：492-495,524,5.DOI:10.16066/j.1672-7002.2025.08.004
慢性鼻窦炎中CXC趋化因子受体1的表达与中性粒细胞浸润的相关性研究
Study on the correlation between CXCR1 expression and neutrophil infiltration in chronic rhinosinusitis
摘要
Abstract
OBJECTIVE To investigate the differential expression of CXC chemokine receptor 1(CXCR1)in chronic rhinosinusitis(CRS)and its correlation with neutrophil infiltration.METHODS A total of 60 CRS patients with nasal polyps(CRSwNP group),30 CRS patients without nasal polyps(CRSsNP group),and 30 patients with deviated nasal septum(control group)were enrolled in this study.ELISA,immunohistochemistry,and reverse transcription polymerase chain reaction were employed to measure CXCR1 expression levels.Correlation analysis was conducted to evaluate the relationship between CXCR1 expression,neutrophil infiltration,and clinical symptom scores.RESULTS CXCR1 was highly expressed in both tissues and serum of CRSwNP patients.Serum CXCR1 levels showed positive correlations with peripheral blood neutrophil counts(r=0.363,P=0.004 4),neutrophil percentage(r=0.323,P=0.011 7),visual analog scale(VAS)score(r=0.328,P=0.010 5),Lund-Kennedy endoscopic score(r=0.331,P=0.009 9),and Lund-Mackay CT score(r=0.262,P=0.045 0).Tissue CXCR1 levels were positively correlated with tissue neutrophil counts(r=0.506,P=0.011 6)and percentage(r=0.564,P=0.004 1).CONCLUSION CXCR1 is highly expressed in CRSwNP patients,and its expression level is positively correlated with the degree of neutrophil infiltration and clinical symptom scores.Higher CXCR1 levels are associated with increased neutrophil migration in both serum and tissues,as well as more severe clinical symptoms.关键词
鼻窦炎/鼻息肉/中性粒细胞/受体,CXCR/CXC趋化因子受体1Key words
Sinusitis/Nasal Polyps/Neutrophils/Receptors,CXCR/chemokine receptor 1引用本文复制引用
郝晴,徐兆男,滕爽,阎柄睿,刘硕,孙亚男..慢性鼻窦炎中CXC趋化因子受体1的表达与中性粒细胞浸润的相关性研究[J].中国耳鼻咽喉头颈外科,2025,32(8):492-495,524,5.基金项目
国家自然科学基金(82473035) （82473035）
黑龙江省自然科学基金(LH2022H009) （LH2022H009）
黑龙江省卫生计生委科技计划项目(20220707011051) （20220707011051）
