中国耳鼻咽喉头颈外科2025，Vol.32Issue(8)：507-511,5.DOI:10.16066/j.1672-7002.2025.08.007
小鼠慢性鼻窦炎伴鼻息肉模型构建的研究展望
Research progress of mouse models of chronic rhinosinusitis with nasal polyps
摘要
Abstract
Chronic sinusitis with nasal polyps(CRSwNP)is a highly heterogeneous chronic inflammatory disease,that persistently impacts patients'quality of life.To date,its etiology and pathogenesis remain incompletely unclear.Animal models serve as crucial tools for exploration of CRSwNP pathogenesis However,there is still a lack of a recognized mature and stable mouse model of CRSwNP in basic research.The stable mouse model of CRSwNP has become a key bottleneck in the analysis of the pathogenesis.This paper systematically reviews existing construction methodologies,inflammatory phenotypes,and applicability of murine CRSwNP models.By comparing their advantages and limitations,we will explore future optimization directions.This review will provide a theoretical basis and foundation for the basic research and clinical precision treatment of CRSwNP.关键词
鼻窦炎/鼻息肉/小鼠/疾病模型,动物/感染/抗原刺激Key words
Sinusitis/Nasal Polyps/Mice/Disease Models,Animal/Infection/antigenic stimulation引用本文复制引用
张振皓,曲朕男,李艳,张罗,蓝凤..小鼠慢性鼻窦炎伴鼻息肉模型构建的研究展望[J].中国耳鼻咽喉头颈外科,2025,32(8):507-511,5.基金项目
国家自然科学基金(82271140) （82271140）
北京市卫生健康委员会市属医学科研院所公益发展改革试点项目(JYY2023-1) （JYY2023-1）
