发光学报2025，Vol.46Issue(9)：1577-1595,19.DOI:10.37188/CJL.20250046
基于镧系发光纳米材料的神经影像与调控
Lanthanide-based Luminescent Nanoparticles for Neuroimaging and Neural Modulation
摘要
Abstract
Neuroscience research,central to both the International Brain Initiative and China's brain science strat-egy,seeks to unravel the complexities of the brain and address neurological disorders,with technological innovation at its core.Key to advancing this field is the development of non-invasive imaging techniques with high spatiotempo-ral resolution and precise,controllable neural modulation methods.Traditional imaging modalities,such as MRI and CT,are constrained by limitations in biological safety,resolution,and tissue penetration.In parallel,external field modulation techniques-based on mechanical,thermal,acoustic,and magnetic principles—are hindered by insuffi-cient spatiotemporal resolution and slow response times.Recently,near-infrared light has emerged as a promising tool in brain science due to its superior tissue penetration and minimal phototoxicity.Among these,lanthanide-based luminescent nanoparticles stand out as key agents for near-infrared light-driven technologies,capable of emitting tun-able ultraviolet,visible,and near-infrared light upon near-infrared excitation.These nanoparticles have found wide-spread applications in biomedical detection,precise diagnostics,and intraoperative navigation.This review provides a comprehensive summary of the latest advancements in the use of lanthanide-based luminescent nanoparticles for neuroimaging and neural modulation,identifies existing technological challenges,and explores future directions from the perspectives of materials science,chemistry,and biomedicine.The review aims to foster interdisciplinary integration,stimulate technological innovation,and inspire breakthroughs in cutting-edge brain science,offering new approaches and strategies for addressing major challenges in life sciences.关键词
镧系发光纳米材料/生物成像/神经调控Key words
lanthanide-based luminescent nanoparticles/bioimaging/neural modulation分类
数理科学引用本文复制引用
陈剑,陈飞翔,邢振宇,刘艳颜..基于镧系发光纳米材料的神经影像与调控[J].发光学报,2025,46(9):1577-1595,19.基金项目
国家自然科学基金委优秀青年科学基金(52322213) （52322213）
国家自然科学基金委面上科学基金(52272269)Supported by National Natural Science Foundation of China Youth Fund(52322213) （52272269）
National Funds for General Projects(52272269) （52272269）
