发光学报2025，Vol.46Issue(9)：1596-1611,16.DOI:10.37188/CJL.20250130
近红外二区发光探针及生物成像
NIR-Ⅱ Luminescent Probes for Bioimaging
摘要
Abstract
Optical imaging in the second near-infrared window(NIR-Ⅱ,1 000-2 000 nm)significantly improves in vivo imaging depth and resolution by reducing tissue scattering and autofluorescence.Over the past decade,the development of diverse NIR-Ⅱ probes and imaging setups has enabled NIR-Ⅱ imaging to overcome the penetration depth limitations of conventional optical techniques,achieving cross-scale dynamic observation from macroscopic an-atomical structures to microscopic molecular events,thereby providing revolutionary tools for biomedical research.This review systematically summarizes recent advances in the design of NIR-Ⅱ luminescent probes and their biomedi-cal applications.The optical properties of various NIR-Ⅱ probes are discussed,with a focus on their innovative ap-plications in anatomical structure imaging,precision tumor diagnosis and therapy,real-time tracking of molecular events in vivo,responsive imaging,microenvironment visualization,and the construction of integrated theranostic platforms.Finally,critical summaries and perspectives on the development and applications of NIR-Ⅱ luminescent materials are presented,highlighting their potential for broader impacts in fundamental research and clinical translation.关键词
光学成像/近红外二区/发光探针Key words
optical imaging/second near-infrared window(NIR-Ⅱ)/luminescent probes分类
数理科学引用本文复制引用
杜平,杨小涵,肖和,孙聆东..近红外二区发光探针及生物成像[J].发光学报,2025,46(9):1596-1611,16.基金项目
国家重点研发计划(2022YFF0710001) （2022YFF0710001）
国家自然科学基金(22031002,21927901)Supported by National Key Research and Development Program of China(2022YFF0710001) （22031002,21927901）
National Natural Science Foun-dation of China(22031002,21927901) （22031002,21927901）
