渔业研究2025，Vol.47Issue(5)：570-582,13.DOI:10.14012/j.jfr.2025086
对虾玻璃苗致病弧菌的毒力进化机制与生态防控策略
Virulence evolution mechanisms and ecological control strategies of Vibrio spp.causing shrimp translucent post-larva vibriosis
摘要
Abstract
[Objective]This review elucidates the pivotal virulence evolution pathway of Vibrio spp.respons-ible for translucent post-larva vibriosis(VpTPV),a disease that causes high mortality in post-larval shrimp.It then clarifies the mechanisms behind the resultant high lethality.Finally,the review aims to provide a foundation for developing novel inhibitors that attenuate these virulence factors and for designing pathogen-specific control strategies.These efforts are crucial for safeguarding broodstock security and supporting the sustainable develop-ment of the aquaculture industry.[Progress]TPV,also referred to as highly lethal Vibrio disease(HLVD),is a severe bacterial affliction that poses a significant threat to the global shrimp aquaculture sector.This disease pre-dominantly affects Penaeus vannamei during the post-larval developmental stages(PL4-PL12),inducing mor-tality rates as high as 90%within 48 hours of onset,leading to substantial economic losses across major shrimp-producing nations,including China and Vietnam.The disease exhibits multi-source pathogenicity,predomin-antly caused by V.parahaemolyticus,but V.alginolyticus and V.campbellii can also be implicated.Importantly,TPV pathogens pose risks of cross-host and cross-regional transmission.Plasmid-encoded toxins represent the core virulence determinants mediating host invasion and tissue damage.Through the expression of toxin com-plexes(Tc)or Vibrio high virulent psrotein 2(VHVP-2),these pathogens induce intestinal barrier collapse and hepatopancreatic necrosis,ultimately leading to tissue degeneration and structural dissolution.At the evolution-ary level,plasmid-borne virulence genes undergo frequent transfer and recombination driven by transposons and type Ⅳ secretion systems(T4SS),generating novel hybrid plasmids and enhancing both adaptability and patho-genicity.To address this bacteriological epizootic that severely compromises penaeid aquaculture,the present work systematically integrates TPV's etiological foundations,molecular pathogenesis,and sustainable mitiga-tion paradigms.This synthesis delineates the diversity of pathogenic Vibrio and the mechanisms of virulence evolution,elucidates toxin-mediated host cellular injury pathways,and establishes sustainable control strategies based on early diagnostics and ecological interventions.[Significance]In response,this review proposes an in-tegrated,ecology-based strategy for disease management:blocking pathogen introduction via broodstock quar-antine and specific pathogen free lines,monitoring and regulating water quality and microbial communities,and complementing with phage therapy,probiotics,and immune enhancers to establish a"source blocking-environ-mental optimization-targeted intervention-rapid response"defense framework.By utilizing this conceptual framework,it is imperative that future research include a thorough examination of toxin-host interaction dynam-ics,alongside the advancement of disease-resistant germplasm development and environmentally adaptive inter-vention technologies.These technologies are necessary to mitigate the risks of epizootic emergence and patho-gen dissemination.关键词
凡纳对虾/对虾玻璃苗弧菌病/副溶血弧菌/致病机制/细菌性疾病Key words
Penaeus vannamei/shrimp translucent post-larva vibriosis/Vibrio parahaemolyticus/pathological mechanism/bacterial diseases分类
农业科技引用本文复制引用
崔晗,刘灵珂,刘海鹏..对虾玻璃苗致病弧菌的毒力进化机制与生态防控策略[J].渔业研究,2025,47(5):570-582,13.基金项目
国家自然科学基金(U23A20251、32303062) （U23A20251、32303062）
中国博士后科学基金(2024T170503、2023M742927) （2024T170503、2023M742927）
厦门大学海洋生物地球化学全国重点实验室杰出博士后基金 （）
