佛山科学技术学院学报（自然科学版）2025，Vol.43Issue(5)：48-53,6.
淫羊藿对BALB/c小鼠生长及免疫性能的影响
Effects of Epimedium brevicornum Maxim on growth performance and immune function in BALB/c mice
摘要
Abstract
This study aimed to investigate the regulatory effects of unfermented Epimedium brevicornum Maxim(EbM)and EbM fermented by lactococcus lactis on the growth performance and immune function of BALB/c mice.Twenty-eight 8-week-old BALB/c mice were divided into seven groups:a control group(N)and six experimental groups.The experimental groups included unfermented EbM at concentrations of 25 μg/mL(L1),45 μg/mL(M1),and 65 μg/mL(H1),as well as lactococcus lactis-fermented EbM at concentrations of 25 μg/mL(L2),45 μg/mL(M2),and 65 μg/mL(H2).Each group comprised four replicates(n=4).Mice in the experimental groups received intragastric administration of the respective treatments once every 24 hours for 7 days,while the control group received saline.The body weight of each mouse was measured before and after the experiment.Blood samples were collected to detect serum immunoglobulins(IgA,IgG,IgM)and the immune cytokine tumor necrosis factor-alpha(TNF-α).Compared with the control group,all experimental groups exhibited a significant reduction in body weight;serum levels of IgA,IgG,and IgM were significantly elevated,while TNF-α levels were significantly decreased in treated mice.These results indicate that both unfermented EbM and lactococcus lactis-fermented EbM enhance immune performance in mice to varying degrees,but result in a significant reduction in body weight.关键词
淫羊藿/益生菌发酵/乳酸乳球菌/BALB/c小鼠/生长性能/免疫性能Key words
Epimedium brevicornum Maxim/probiotic fermentation/lactococcus lactis/BALB/c mice/growth performance/immune function分类
医药卫生引用本文复制引用
伍俊杰,刘汉雯,王一臣,李智丽..淫羊藿对BALB/c小鼠生长及免疫性能的影响[J].佛山科学技术学院学报（自然科学版）,2025,43(5):48-53,6.基金项目
国家重点研发计划项目(2022YFD1601307) （2022YFD1601307）
