医学分子生物学杂志2025，Vol.22Issue(5)：430-434,5.DOI:10.3870/j.issn.1672-8009.2025.05.003
舌鳞癌中EGFR的表达与扩增的临床意义
Clinical Significance of EGFR Expression and Amplification in Tongue Squamous Cell Carcinoma
摘要
Abstract
Objective To explore the clinical significance of EGFR expression and amplifica-tion in tongue squamous cell carcinoma.Methods Detection of EGFR using immunohistochemis-try and FISH was conducted in 34 cases of tongue squamous cell carcinoma and their adjacent tis-sues,along with one case of pseudoepitheliomatous hyperplasia of the tongue in tissue chips.Re-sults The expression and amplification rates of EGFR in tongue squamous cell carcinoma were higher than those in adjacent normal tissues.Specifically,the expression rate of EGFR in cancer tis-sues was 63.6％(21 out of 33 samples),while in normal tissues,it was 0％(0 out of 33 sam-ples).Regarding amplification,the rate in cancer tissues was 5.9％(2 out of 33 samples),whereas it remained at 0％(0 out of 33 samples)in normal tissues.EGFR expression was not as-sociated with age,gender,tissue grading,or clinical stage,but it was associated with lymph node metastasis.Conclusion Detection of EGFR is important for differentiating tongue squamous cell carcinoma in clinical pathology.The overexpression of EGFR protein is partially due to an increase in copy number,and an elevated level of EGFR indicates a poor clinical prognosis.关键词
舌鳞癌/表皮生长因子受体/免疫组织化学/荧光原位杂交Key words
oral tongue squamous cell carcinoma/epidermal growth factor receptor/immuno-histochemistry/fluorescence in situ hybridization分类
医药卫生引用本文复制引用
汪园园,赵晓妮,杨喆,张娇娇,夏妮娜,李晓锋,刘希,魏晓云..舌鳞癌中EGFR的表达与扩增的临床意义[J].医学分子生物学杂志,2025,22(5):430-434,5.基金项目
陕西省国际科技合作与交流计划项目(No.2016KW-001) This work was supported by a grant from the International Scientific and Technological Cooperation and Exchange Program of Shaanxi Province(No.2016KW-001) （No.2016KW-001）
