医学分子生物学杂志2025，Vol.22Issue(5)：476-481,6.DOI:10.3870/j.issn.1672-8009.2025.05.009
IP-10、IL-2、MCP-1、INF-γ血液浓度检测在活动性肺结核诊断中的应用研究
Application of Serum IP-10,IL-2,MCP-1 and INF-γ Level in Diag-nosis of Active Pulmonary Tuberculosis
摘要
Abstract
Objective To explore the application of serum interferon-gamma-induced protein 10(IP-10),interleukin-2(IL-2),monocyte chemoattractant protein-1(MCP-1),and interfer-on-ganma(INF-γ)in the diagnosis of active tuberculosis(ATB).Methods The clinical data of 110 ATB patients who visited Hongya County Traditional Chinese Medicine Hospital from November 2023 to November 2024 were retrospectively analyzed as the observation group.Another 90 patients with other lung diseases and 60 healthy individuals undergoing physical examinations during the same period were selected as the lung disease group and the control group,respectively.The levels of serum IP-10,IL-2,MCP-1 and INF-γ in the three groups were compared.The relationship be-tween IP-10,IL-2,MCP-1,INF-γ and ATB was analyzed,and the receiver operating characteris-tic(ROC)curve was drawn to explore the diagnostic value of IP-10,IL-2,MCP-1,and INF-γ for ATB.Results The levels of IP-10,IL-2,MCP-1,and INF-γ in the observation group were higher than those in the lung disease group and the control group(P＜0.05);the levels of IP-10,IL-2,MCP-1,and INF-γ in the lung disease group were higher than those in the control group(P＜0.05).ROC curve analysis showed that the combined diagnosis of ATB with IP-10,IL-2,MCP-1,and INF-γ(AUC:0.813,95％CI:0.784-0.842)was superior to the single indicators of IP-10(AUC:0.663,95％CI:0.645-0.681),IL-2(AUC:0.627,95％CI:0.611-0.643),MCP-1(AUC:0.721,95％CI:0.685-0.757),and INF-γ(AUC:0.734,95％CI:0.692-0.776)(P＜0.05).Logistic analysis revealed that elevated IP-10(OR:3.435,95％CI:1.874-4.996),elevated IL-2(OR:1.314,95％CI:1.264-6.178),elevated MCP-1(OR:3.691,95％CI:2.521-5.561),and elevated INF-γ(OR:3.710,95％CI:1.584-5.836)were independent risk factors for the occurrence of ATB(P＜0.05).Conclusion IP-10,IL-2,MCP-1,and INF-γ are highly expressed in ATB,and elevated levels of IP-10,IL-2,MCP-1,and INF-γ are risk factors for the occurrence of ATB.The combined use of IP-10,IL-2,MCP-1,and INF-γ in the diagnosis of ATB can improve the accuracy of the results.关键词
活动性肺结核/γ干扰素诱导蛋白10/白细胞介素-2/单核细胞趋化因子-1/干扰素-γKey words
active tuberculosis/interferon γ-inducible protein-10/interleukin-2/monocyte chemoattractant protein-1/interferon-gamma分类
医药卫生引用本文复制引用
王波,韩伟..IP-10、IL-2、MCP-1、INF-γ血液浓度检测在活动性肺结核诊断中的应用研究[J].医学分子生物学杂志,2025,22(5):476-481,6.基金项目
河南省医学科技攻关计划项目(No.LHGJ20220594) This work was supported by a grant from the Medical Science and Technology Tackling Program of Henan Province(No.LHGJ20220594) （No.LHGJ20220594）
