国际医学放射学杂志2025，Vol.48Issue(5)：509-515,7.DOI:10.19300/j.2025.L22042
心脏MR特征追踪技术对HIV感染病人心肌应变的研究
Myocardial strain analysis in HIV-infected patients using CMR feature tracking technique
摘要
Abstract
Objective To investigate local cardiac functional changes in individuals infected with human immunodeficiency virus(HIV)using cardiac magnetic resonance feature tracking(CMR-FT)technology.Methods A total of 47 HIV-infected patients were prospectively enrolled,including 30 asymptomatic individuals(Asymptomatic HIV group),17 patients with acquired immunodeficiency syndrome(AIDS group),and 21 age-matched healthy controls(HC group).Overall cardiac function was evaluated using CMR cine sequences,and myocardial strain parameters were measured with CMR-FT technology.The left ventricle was divided into 16 segments,and segmental strain reduction was defined using thresholds of global longitudinal strain(GLS)=-13.4％,global circumferential strain(GCS)=-16.8％,and global radial strain(GRS)=43.9％.The proportion of segments with reduced strain was compared across the three groups.Differences in clinical and imaging data among the three groups were compared.Differences in clinical information between the asymptomatic HIV group and the AIDS group were compared using the chi-square test or Fisher's exact test.Results For global cardiac function parameters,both the asymptomatic HIV group and the AIDS group had significantly lower left ventricular ejection fraction(LVEF),right ventricular ejection fraction(RVEF),right ventricular end-systolic volume(RVESV),and right ventricular cardiac output(RVCO)compared to the HC group(all P＜0.05).However,there were no significant differences in overall cardiac function parameters between the asymptomatic HIV and AIDS groups(all P＞0.05).Regarding myocardial strain parameters,GLS,GCS,and GRS were significantly lower in both the asymptomatic HIV group and the AIDS group compared to the HC group(all P＜0.05),with no statistically significant differences between the asymptomatic HIV and AIDS groups for these parameters(all P＞0.05).In the analysis of segmental GCS,the AIDS group showed a higher proportion of segments with reduced GCS compared to the asymptomatic HIV group,while no significant differences were found in the segmental strain parameters of other types(all P＞0.05).Conclusion GCS assessed by CMR-FT technology can serve as an imaging biomarker for early cardiac function impairment following HIV infection,providing valuable information for clinical assessment.关键词
心脏磁共振成像/人类免疫缺陷病毒/心功能/心肌应变Key words
Cardiac magnetic resonance imaging/Human immunodeficiency virus/Cardiac function/Myocardial strain分类
医药卫生引用本文复制引用
晏乘曦,李瑞利,张莉,樊佳怡,张新军,李宏军,张月浪..心脏MR特征追踪技术对HIV感染病人心肌应变的研究[J].国际医学放射学杂志,2025,48(5):509-515,7.基金项目
北京市优秀人才培养资助项目(20180000021469G290) （20180000021469G290）
