神经损伤与功能重建2025，Vol.20Issue(9)：517-522,6.DOI:10.16780/j.cnki.sjssgncj.20240399
基于孟德尔随机化研究阿尔兹海默病领域热点的可视化分析
Visual Analysis of Reasearch Hotspots in the Field of Alzheimer's Disease Based on Mende-lian Randomization
摘要
Abstract
Objective:To explore the hot topics and development trends in the field of Alzheimer's disease(AD)through Mendelian randomization(MR)studies.Methods:Relevant English literature on MR studies of AD was retrieved from the Web of Science Core Collection database,spanning from the inception of the database to March 2024.CiteSpace 6.2.R4 was utilized for visual analysis of authors,countries,institutions,co-citation of documents,co-occurrence of keywords,and keyword clustering,and a knowledge map was constructed.Additionally,the PatSnap Global New Drug Intelligence Database was consulted to investigate the drug development status of biomarkers related to AD.Results:A total of 347 English articles were included after deduplication,with an increasing trend in annual publication volume.British scholar Ben-shlomo Yoav had the highest betweenness centrality.The top three countries in terms of publication volume were China,the United States,and the United Kingdom,while the top three countries in betweenness centrality were Poland,France,and Canada.China had the highest publication volume but only collaborated with the United States and the Netherlands.The top three institutions were University College London,Harvard University,and Fudan University.In the keyword clustering map,"#0 risk factors"was most closely related to AD biomarkers,with amyloid precursor protein(APP)and tau(TAU)emerging as more promising drug targets.Conclusion:MR studies on AD are mainly conducted in China,the UK,and the US.The primary research focus is on risk factors for AD onset,such as amyloid protein in cerebrospinal fluid.Related studies have identified APP and TAU as more important biomarkers and drug targets.关键词
阿尔兹海默病/孟德尔随机化/可视化分析/生物标志物Key words
Alzheimer's disease/Mendelian randomization/visual analysis/biomarker分类
医药卫生引用本文复制引用
李小竟,李心乐,卢秀煦,赖鸿鹄,肖海伦,孙炜,吕光耀..基于孟德尔随机化研究阿尔兹海默病领域热点的可视化分析[J].神经损伤与功能重建,2025,20(9):517-522,6.基金项目
国家中医药管理局第四批中医临床(基础)优秀人才项目(J20184832009) （基础）
深圳市"医疗卫生三名工程"项目(SZZYSM202106009) （SZZYSM202106009）
