神经损伤与功能重建2025，Vol.20Issue(9)：538-542,551,6.DOI:10.16780/j.cnki.sjssgncj.20230575
组织金属蛋白酶抑制剂-1在中枢神经系统疾病中的研究进展
Recent Advances in Research on Organizing Metalloproteinase Inhibitor-1 in Central Nervous System Diseases:A Review
摘要
Abstract
Central nervous system(CNS)disorders,characterized by dysfunction and pathology in neurovascular units,represent a leading cause of disability,with high incidence and protracted courses.Tissue inhibitors of metalloproteinase 1(TIMP-1)serve as natural inhibitors of matrix metalloproteinase 9(MMP-9)and are critical for maintaining extracellular matrix homeostasis.Recent research has unveiled novel,MMP-independent functions of TIMP-1,as it acts as a multifaceted cell factor by binding to cell surface receptors.Fluctuations in TIMP-1 levels directly correlate with the occurrence and prognosis of CNS diseases,making TIMP-1 a promising target for promoting neurovascular unit repair.This review summarizes the recent research progress of TIMP-1 in CNS diseases,aiming to comprehensively explore its roles and mechanisms in the development of cerebrovascular injury,epilepsy,and neurodegenerative diseases.关键词
中枢神经系统疾病/组织金属蛋白酶抑制剂-1/组织金属蛋白酶-9/血脑屏障/细胞外基质/预后Key words
central nervous system disorders/tissue inhibitors of metalloproteinase 1/tissue metalloproteinase-9/blood-brain barrier/extracellular matrix/prognosis分类
医药卫生引用本文复制引用
赵留洋,罗娇,周明超,王玉龙..组织金属蛋白酶抑制剂-1在中枢神经系统疾病中的研究进展[J].神经损伤与功能重建,2025,20(9):538-542,551,6.基金项目
国家自然科学基金(通阳宽胸颗粒通过抑制外泌体膜蛋白α9β1/α4β1和VCAM1的表达改善AS炎细胞浸润的作用及机制研究,No.82205065 （）
肥胖脂肪外泌体miRNA-199a/214抑制ECM重塑加重缺血性脑卒中神经血管单元损伤的机制研究,No.82272598) （）
深圳市科学技术创新委员会(利用单个细胞外囊泡测序新技术建立基于TIMP1/MMP9的缺血性脑卒中活动能力康复效果精准预测模型及其机制研究,No.JCYJ20220530150407015) （利用单个细胞外囊泡测序新技术建立基于TIMP1/MMP9的缺血性脑卒中活动能力康复效果精准预测模型及其机制研究,No.JCYJ20220530150407015）
