保健医学研究与实践2025，Vol.22Issue(6)：58-63,6.DOI:10.11986/j.issn.1673-873X.2025.06.09
血清LTBP-2、PON-1水平对支气管哮喘患儿病情严重程度及急性发作的预测价值
Evaluation value of LTBP-2 and PON-1 levels on the condition and acute exacerbation in children with bronchial asthma
摘要
Abstract
Objective To investigate the evaluation value of serum latent transforming growth factor β-binding protein-2(LT-BP-2)and paraoxonase-1(PON-1)levels on the condition and acute exacerbation in children with bronchial asthma,aiming to provide a reference for clinical treatment.Methods A total of 116 children with bronchial asthma admitted to First Hos-pital of Qinhuangdao from August 2020 to June 2024 were selected as research participants.Based on disease severity,they were assigned to a mild group(n=52),moderate group(n=38),and severe group(n=26).According to whether the children were in an acute attack phase,they were allocated to an acute group(n=71)and a remission group(n=45).Addi-tionally,100 healthy children undergoing physical examinations during the same period were selected as a healthy group.General data(e.g.,age,sex)and serum LTBP-2 and PON-1 levels were collected from all participants.Forced expiratory volume in one second(FEV1)and FEV1 as a percentage of predicted value were measured in children with bronchial asthma.Results LTBP-2 levels in the mild,moderate,and severe groups were significantly higher than those in the healthy group,while serum PON-1 levels were lower than those in the healthy group,with statistically significant differences(P＜0.05).As disease severity increased,LTBP-2 levels gradually rose,and PON-1 levels gradually declined,with statistically signifi-cant differences(P＜0.05).LTBP-2 levels in the acute group were higher than those in the remission group,while PON-1 levels,FEV1,and FEV1 as a percentage of predicted value were lower than those in the remission group,with statistically significant differences(P＜0.05).LTBP-2 levels in children with bronchial asthma were positively correlated with disease severity and negatively correlated with FEV1 and FEV1 as a percentage of predicted value(P＜0.001).PON-1 levels were negatively correlated with disease severity and positively correlated with FEV1 and FEV1 as a percentage of predicted value(P＜0.001).The areas under the curve(AUC)for serum LTBP-2,PON-1,and LTBP-2 plus PON-1 in evaluating acute exacerbation in children with bronchial asthma were 0.784(95％CI:0.739-0.834),0.837(95％CI:0.792-0.887),and 0.919(95％CI:0.874-0.969),respectively.Conclusion Serum LTBP-2 and PON-1 levels are significantly correla-ted with disease severity and lung function in children with bronchial asthma.Clinically,monitoring changes in these two in-dicators can help assess disease progression and acute attack risk.Moreover,the study shows that combined detection of both indicators has a higher evaluation value for acute exacerbation in children with bronchial asthma than single-indicator detection,providing a more reliable reference for clinical diagnosis and treatment.关键词
转化生长因子结合蛋白-2/对氧磷脂酶-1/支气管哮喘/急性发作期Key words
Latent transforming growth factor β-binding protein-2/Paraoxonase-1/Bronchial asthma/Acute exacerbation phase分类
医药卫生引用本文复制引用
阴悦,李若晗,柴小龙,张艳玲,王靓靓,刘文杰,苏文硕..血清LTBP-2、PON-1水平对支气管哮喘患儿病情严重程度及急性发作的预测价值[J].保健医学研究与实践,2025,22(6):58-63,6.基金项目
河北省卫生健康委员会医学科学研究计划项目(20191374). （20191374）
