河北工业科技2025，Vol.42Issue(5)：444-455,12.DOI:10.7535/hbgykj.2025yx05006
基于基准关联度和AHP-CRITIC法的飞龙掌血配方颗粒制备工艺研究
Study on the preparation process of Toddalia asiatica formula granules based on benchmark correlation degree and AHP-CRITIC comprehensive evaluation method
摘要
Abstract
This study evaluated the consistency of product quality between modern and traditional preparation processes for Toddalia asiatica formula granules,and aimed to establish a stable and controllable production process.Starting from the concept of quality by design,based on single factor experiments,the key factors affecting the extraction,soaking time,number of extractions,extraction time,and water volume were identified.Hesperidin content,toddaloactone content,nitidine chloride content,characteristic peak similarity,and extract yield were used as evaluation indicators.The extraction process using response surface methodology combined with reference correlation and an AHP-CRITIC comprehensive evaluation method was optimized,and suitable parameters for concentration,drying,and granulation were clarified through single-factor tests.The results indicate that the optimal extraction conditions are adding eight times the amount of water,extracting once,and extracting for 120 minutes.Under these conditions,the comprehensive score reaches 53.620.The suitable concentration density is 1.125-1.250 g/cm3,under a vacuum of 50-200 MPa,and temperature of 50-90℃.The study recommends spray drying for the liquid extract,with a feed rate of 8-14 mL/min and inlet temperature of 160-180℃.For granulation,dry processing is selected using dextrin as filler,with drug-excipient ratio from 1∶0.8 to 1∶1.Roller pressure is set at 100-120 bar,feeding speed at 2.42-2.62 rad/s,and roller speed at 0.29-0.42 rad/s.The proposed process is reasonable and feasible,which provides a basis for industrial production and quality control of Toddalia asiatica formula granules.关键词
中药药剂学/飞龙掌血配方颗粒/提取工艺/制备工艺/Box-Behnken响应面法Key words
Chinese medicine pharmaceutics/Toddalia asiatica formula granules/extraction process/preparation process/Box-Behnken response surface method分类
医药卫生引用本文复制引用
梁秀珍,梁资就,张怡婕,覃慧杰,蒋林,陈清,黄小洪,谢孟姣,李芳婵..基于基准关联度和AHP-CRITIC法的飞龙掌血配方颗粒制备工艺研究[J].河北工业科技,2025,42(5):444-455,12.基金项目
广西重点研发计划(桂科AB21196051) （桂科AB21196051）
广西壮族自治区高校黄大年式教师团队建设项目(桂教教师[2023]31号) （桂教教师[2023]31号）
