中国实用神经疾病杂志2025，Vol.28Issue(10)：1211-1215,5.DOI:10.12083/SYSJ.241775
脓毒症相关性脑病患者细胞炎性因子的临床价值
Clinical value of inflammatory cytokines in sepsis-related encephalopathy
摘要
Abstract
Objective To investigate the value of detecting inflammatory cytokines in sepsis-related encephalopathy(SAE).Methods A total of 244 sepsis patients admitted to Zhengzhou People's Hospital from February 2021 to February 2024 were enrolled and divided into SAE group(76 cases)and non-SAE group(168 cases)based on the occurrence of sepsis encephalopathy.General baseline data,GCS score,SOFA score,APACHEⅡ score,white blood cell count,neutrophil ratio,neutrophil count,lymphocyte ratio,lymphocyte count,platelet count,neutrophil-to-lymphocyte ratio(NLR),whole blood C-reactive protein(CRP),blood lactate,serum procalcitonin(PCT),and serum inflammatory factors(IL-2,IL-4,IL-6,IL-8,IL-10,IL-1β,IFN-γ,TNF-α)were collected in both groups.Statistical comparisons were made between the two groups for various indicators,and Logistic regression model was constructed for significant factors.The ROC curve was used to evaluate the predictive performance of independent risk factors and their combined detection for SAE occurrence.Results The SAE group had higher rates of previous cerebrovascular disease history,SOFA score,APACHEⅡ score,white blood cell count,neutrophil ratio,neutrophil count,NLR,CRP,PCT,IL-8,IL-6,IL-1β,and TNF-α compared to the non-SAE group,while GCS score and lymphocyte ratio were lower in the SAE group,with statistically significant differences(P＜0.05).GCS score,SOFA score,IL-1β,and TNF-α were identified as independent risk factors for SAE(P＜0.05).The AUC of GCS score for predicting SAE was 0.816(95％CI:0.762-0.870),with the sensitivity of 84％,and the specificity of 77.8％.The AUC of SOFA score was 0.778(95％CI:0.712-0.844),with the sensitivity of 60％,and the specificity of 85.6％.The AUC of serum IL-1βwas 0.637(95％CI:0.564-0.710),with the sensitivity of 60％,and the specificity of 67.1％.The AUC of serum TNF-α was 0.603(95％CI:0.521-0.685),with the sensitivity of 52％,and the specificity of 76.6％.The AUC of the combined prediction was 0.895(95％CI:0.853-0.938),with the sensitivity of 90.7％and the specificity of 76.6％.Conclusion GCS score,SOFA score,IL-1β,and TNF-α exhibit high clinical predictive value for sepsis patients with concurrent SAE.关键词
脓毒症/炎性因子/脓毒症相关性脑病/GCS评分/SOFA评分/IL-1β/TNF-α/血清/预测效能Key words
Sepsis/Inflammatory factors/Sepsis-associated encephalopathy/Clinical value/GCS score/SOFA score/IL-1β/TNF-α/Serum/Predictive efficiency分类
医药卫生引用本文复制引用
杜家琇,杨冬冬,赵萌,乔月,陈莉莉,王红宇..脓毒症相关性脑病患者细胞炎性因子的临床价值[J].中国实用神经疾病杂志,2025,28(10):1211-1215,5.基金项目
河南省医学科技攻关计划项目(编号:LHGJ20220785) （编号:LHGJ20220785）
