中国实用神经疾病杂志2025，Vol.28Issue(10)：1234-1239,6.DOI:10.12083/SYSJ.240818
青年动脉粥样硬化型脑梗死的临床特点及严重程度相关因素分析
Clinical features and related factors for atherosclerosis cerebral infarction in young patients
摘要
Abstract
Objective To investigate the clinical characteristics of young patients with atherosclerotic cerebral infarction and analyze the relevant influencing factors of the severity of cerebral infarction.Methods Forty young patients aged 18-49 years,who were hospitalized in the Third Affiliated Hospital of Anhui Medical University from June 2021 to August 2022 due to acute atherosclerotic cerebral infarction,were recruited as the young stroke group.Additionally,30 middle-aged and elderly patients over 49 years old with acute atherosclerotic cerebral infarction during the same period were selected as the middle-aged and elderly stroke group.A comparison of serological and imaging indicators between the two groups was conducted.The severity of cerebral infarction was evaluated using NIHSS score.Spearman correlation analysis was employed to determine the correlations between age,gender,serum biochemical indicators,smoking history,drinking history,hypertension history,neutrophil to lymphocyte ratio(NLR),platelet to lymphocyte ratio(PLR),mean arterial pressure(MAP),albumin to globulin ratio,homocysteine(Hcy),activated partial thromboplastin time(APTT),international normalized ratio(INR),D-dimer,creatinine,urea nitrogen,direct bilirubin(DBil),indirect bilirubin(IBil),and the NIHSS score.Results The proportion of male patients and those with hyperuricemia was significantly higher in the young stroke group compared to the middle-aged and elderly stroke group.Meanwhile,NIHSS score of the young stroke group was significantly lower than that of the middle-aged and elderly stroke group(P＜0.05).The levels of blood glucose,triglycerides,glycated hemoglobin,creatinine,and DBil in the young stroke group were higher than those in the middle-aged and elderly stroke group.In contrast,the levels of high-density lipoprotein,IBil,and INR were lower,and the APTT was shorter in the young stroke group compared to the middle-aged and elderly stroke group(P＜0.05).The proportion of basal ganglia infarction and internal carotid artery occlusion in the young stroke group was lower than that in the middle-aged and elderly stroke group,while the proportion of anterior cerebral artery occlusion was higher in the young stroke group than that in the middle-aged and elderly stroke group(P＜0.05).Spearman correlation analysis indicated significant correlations between age,smoking,IBil,and the NIHSS score(r=0.30,P＜0.05;r=0.74,P＜0.05;r=0.40,P＜0.05,respectively).Conclusion There are distinct differences in serological indicators and imaging manifestations between young patient and middle-aged and elderly patient with atherosclerotic cerebral infarction.Smoking,advanced age,and abnormal serum bilirubin levels may be risk factors for severe stroke.关键词
青年卒中/脑梗死/动脉粥样硬化/血清学/影像学/危险因素Key words
Young stroke/Cerebral infarction/Atherosclerosis/Serology/Imaging/Risk factors分类
医药卫生引用本文复制引用
黄超,董斌..青年动脉粥样硬化型脑梗死的临床特点及严重程度相关因素分析[J].中国实用神经疾病杂志,2025,28(10):1234-1239,6.基金项目
安徽医科大学校科研基金项目(编号:2020xkj237) （编号:2020xkj237）
