基础医学与临床2025，Vol.45Issue(10)：1262-1269,8.DOI:10.16352/j.issn.1001-6325.2025.10.1262
老年恶性肿瘤患者肾功能不全的抗肿瘤治疗挑战与管理策略
Challenges and management strategies of anti-tumor treatment for renal insufficiency in elderly patients with malignant tumors
摘要
Abstract
The incidence of malignant tumors among elderly patients is increasing.Influenced by multiple factors such as aging,tumor,and drug,this population exhibits a high prevalence of renal insufficiency.However,there remains a scarcity of research data and significant challenges in clinical management.This article systematically an-alyzes the challenges faced in administering anti-tumor therapies to elderly patients with renal insufficiency and pro-poses management strategies.Optimization approaches include precise assessment of renal function,selection of nephrotoxicity-sparing medications,appropriate dose adjustments,implementation of preventive measures,and em-phasis on comprehensive geriatric assessment and multidisciplinary collaboration.Renal injury management should be individualized,with considerations for special populations such as renal transplant recipients and dialysis pa-tients.Future efforts should focus on biomarker discovery and the development of low-nephrotoxicity therapeutic agents to address these complex clinical challenges.关键词
肾功能不全/抗肿瘤治疗/老年患者Key words
renal insufficiency/anti-tumor treatment/elderly patients分类
医药卫生引用本文复制引用
曾骋宇,邱维,宋华,郭欣颖,应红艳..老年恶性肿瘤患者肾功能不全的抗肿瘤治疗挑战与管理策略[J].基础医学与临床,2025,45(10):1262-1269,8.基金项目
中央高水平医院临床科研专项提升项目(2022-PUMCH-B-050) （2022-PUMCH-B-050）
