江苏大学学报（医学版）2025，Vol.35Issue(5)：437-441,5.DOI:10.13312/j.issn.1671-7783.y240177
免疫检查点单核苷酸多态性与原发性肝癌患者术后预后的相关性
Association between immune checkpoint single nucleotide polymorphisms and prognosis in surgical treatment of primary hepatocellular carcinoma
摘要
Abstract
Objective:To investigate the association of single nucleotide polymorphisms(SNP)of programmed death receptor 1(PD-1)and cytotoxic T lymphocyte-associated antigen-4(CTLA-4)with postoperative prognosis of patients with hepatocellular carcinoma(HCC).Methods:A total of 395 HCC patients who underwent partial hepatectomy from January 2002 to December 2012 were included.The SNP loci of PD-1 and CTLA-4 were identified by genotyping,and the survival status of the patients was evaluated by the Kaplan-Meier survival curve,the survival rate was compared by using the Log-Rank test;multivariate analysis of the factors influencing the prognosis of patients was further conducted through the Cox proportional hazards model.Results:A total of 7 SNP loci were detected,including 4 SNP of the PD-1 gene(rs10204525,rs36084323,rs2227982,rs7421861)and 3 SNP of the CTLA-4 gene(rs16840252,rs733618,rs231775).Among them,rs10204525,rs36084323 and rs16840252 were significantly correlated with the postoperative prognosis of HCC patients(P<0.05),while no significant correlation was shown at other loci(P>0.05).The results of Cox regression analysis showed that rs10204525,rs36084323 and rs16840252 were independent influencing factors for the postoperative prognosis of HCC patients(P<0.05).Conclusion:The SNP rs10204525 and rs36084323 of the PD-1 gene and the SNP rs16840252 of the CTLA-4 gene were significantly associated with the postoperative prognosis of HCC patients and were independent influencing factors.关键词
肝细胞肝癌/程序性死亡受体1(PD-1)/细胞毒性T淋巴细胞相关抗原4(CTLA-4)/单核苷酸多态性/预后Key words
hepatocellular carcinoma/programmed death receptor 1(PD-1)/cytotoxic T lymphocyte associated antigen-4(CTLA-4)/single nucleotide polymorphism/prognosis分类
医药卫生引用本文复制引用
张兆延,蒋佳凯,柏凯,张盛..免疫检查点单核苷酸多态性与原发性肝癌患者术后预后的相关性[J].江苏大学学报（医学版）,2025,35(5):437-441,5.基金项目
常州市应用基础研究计划项目(CJ20220255) （CJ20220255）
南京医科大学常州医学中心一般研究项目(CMCB202218) （CMCB202218）
