常州大学学报（自然科学版）2025，Vol.37Issue(5)：75-85,11.DOI:10.3969/j.issn.2095-0411.2025.05.009
柚皮素-葡甲胺共无定形复合物的制备与成药性研究
Preparation and druggability of naringenin-meglumine co-amorphous complex
摘要
Abstract
In this study,the co-amorphous system of naringenin(NAR)was prepared with meglu-mine(MEG)to enhance its low water solubility.The formed co-amorphous system(NAR-MEG CM)was confirmed by powder X-ray diffraction(PXRD)and differential scanning calorimetry(DSC)ana-lyses.Besides,fourier transform infrared spectoscopy(FT-IR)and radial distribution function(RDF)results suggested that the NAR-MEG CM was driven by the strong hydrogen bond interactions between the C=O group of NAR and the—OH/—NH group of MEG.Furthermore,NAR-MEG CM performed significantly improved supersaturated dissolution and maintained a long-term supersat-urated concentration.Meanwhile,NAR-MEG CM showed significantly enhanced physical stability than amorphous NAR.Therefore,this study effectively solved the solubility problem of NAR and the designed NAR-MEG CM maintained excellent physical stability,which could provide a guidance for the de-velopment of NAR co-amorphous system.关键词
柚皮素/葡甲胺/共无定形体系/溶出/物理稳定性Key words
naringenin/meglumine/co-amorphous system/dissolution/physical stability分类
医药卫生引用本文复制引用
韩加伟,孙雯,梁银凡,李佳玥,鲍呈圣,张黄亮,王珏,刘晓骞..柚皮素-葡甲胺共无定形复合物的制备与成药性研究[J].常州大学学报（自然科学版）,2025,37(5):75-85,11.基金项目
国家自然科学基金青年科学基金资助项目(82404546) （82404546）
中国博士后科学基金面上资助项目(2023M740377,2024M752702) （2023M740377,2024M752702）
江苏省自然科学基金青年基金资助项目(BK20240964) （BK20240964）
常州市科技项目领军型创新人才引进培育项目(CQ20240110). （CQ20240110）
