常州大学学报（自然科学版）2025，Vol.37Issue(5)：86-96,11.DOI:10.3969/j.issn.2095-0411.2025.05.010
白芍-当归抑制滑膜细胞增殖以缓解类风湿关节炎
Drug-pair Radix Paeoniae Alba-Radix Angelica Sinensis inhibits synovial fibroblast's proliferation to relieve rheumatoid arthritis
摘要
Abstract
This study established a collagen-induced arthritis(CIA)rat model to investigate the effects of the drug pair Radix Paeoniae Alba-Radix Angelica Sinensis on arthritis score,toe swelling,the ser-um and tissue levels of inflammatory factors in CIA rats.A primary rat synovial fibroblast model was also established,and treated with the drug-pair Radix Paeoniae Alba-Radix Angelica Sinensis,solo Radix Paeoniae Alba and Radix Angelica Sinensis extracts,respectively.Synovial fibroblast prolifera-tion,migration,MMP-2/9 activity,intracellular signaling protein expressions,and mitochondrial membrane potential were detected.The results showed that the drug-pair reduced joint swelling and arthritis scores and down regulated the levels of inflammatory factors in serum and tissue homogenate in CIA rats.In vitro,the drug-pair inhibited cell proliferation and induced apoptosis via the TLR-4/NF-кB signaling pathway and the BAX/Bcl-2/mitochondrial pathway.This study revealed the phar-macological mechanism of the drug-pair Radix Paeoniae Alba-Radix Angelica Sinensis in alleviating rheumatoid arthritis.关键词
类风湿关节炎/胶原诱导的关节炎/滑膜成纤维细胞/药对白芍-当归Key words
rheumatoid arthritis/collagen-induced arthritis/synovial fibroblast/drug-pair Radix Pae-oniae Alba-Radix Angelica Sinensis分类
医药卫生引用本文复制引用
李秀文,练学娇,谢毅鹏,周晓鹰..白芍-当归抑制滑膜细胞增殖以缓解类风湿关节炎[J].常州大学学报（自然科学版）,2025,37(5):86-96,11.基金项目
2022年江苏省研究生科研与实践创新计划资助项目(SJCX22_1317) （SJCX22_1317）
常州大学大学生创新创业基金资助项目(2022-B-19). （2022-B-19）
