检验医学与临床2025，Vol.22Issue(17)：2305-2309,2315,6.DOI:10.3969/j.issn.1672-9455.2025.17.001
血清NLR、CD64指数对重症肺炎的诊断价值
Diagnostic value of serum NLR and CD64 index in severe pneumonia
摘要
Abstract
Objective To investigate the diagnostic value of serum neutrophil/lymphocyte ratio(NLR)and leukocyte differentiation antigen 64(CD64)index for severe pneumonia.Methods A total of 120 patients with severe pneumonia admitted to Nanjing Pukou Hospital of Traditional Chinese Medicine in Jiangsu Prov-ince from April 2022 to April 2024 were selected as the severe pneumonia group,and 120 patients with com-mon pneumonia admitted to Nanjing Pukou Hospital of Traditional Chinese Medicine in Jiangsu Province dur-ing the same period were selected as the mild pneumonia group.The serum neutrophil count and lymphocyte count of the two groups were detected,and NLR was calculated.The fluorescence intensity of serum CD64 in the two groups was detected by flow cytometry,and the CD64 index was calculated.The serum levels of tumor necrosis factor-α(TNF-α),interleukin(IL)-1β and IL-6 were detected by enzyme-linked immunosorbent as-say.Pearson correlation analysis was used to analyze the correlation between serum NLR,CD64 index and fac-tors IL-1β,IL-6,TNF-α levels in patients with severe pneumonia.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum NLR,CD64 index alone and combined detection in severe pneumonia.Multivariate Logistic regression was used to analyze the influencing factors of severe pneu-monia in patients with pneumonia.Results The neutrophil count,clinical pulmonary infection score,and acute physiology and chronic health evaluation Ⅱ score in the severe pneumonia group were higher than those in the mild pneumonia group,and the lymphocyte count was lower than that in the mild pneumonia group,and the differences were statistically significant(P＜0.05).The NLR,CD64 index and the levels of IL-1β,IL-6 and TNF-α in the severe pneumonia group were higher than those in the mild pneumonia group,and the differ-ences were statistically significant(P＜0.05).Pearson correlation analysis showed that serum NLR and CD64 index were positively correlated with IL-1β,IL-6 and TNF-α levels in patients with severe pneumonia(P＜0.05).The results of multivariate Logistic regression analysis showed that the increase of serum NLR,CD64 index,neutrophil count and TNF-α,IL-1β,IL-6 levels were risk factors for severe pneumonia in patients with pneumonia(P＜0.05),and the increase of lymphocyte count was a protective factor for severe pneumonia in patients with pneumonia(P＜0.05).The results of ROC curve analysis showed that the area under the curve(AUC)of serum NLR,CD64 index and their combination in the diagnosis of severe pneumonia were 0.843,0.800 and 0.921 respectively.The AUC of the combination of NLR and CD64 index in the diagnosis of severe pneumonia was greater than that of NLR and CD64 index alone(Z=3.391,4.619,P＜0.05).Conclusion Serum NLR and CD64 index are increased in patients with severe pneumonia,and the combination of the two has high diagnostic value for severe pneumonia.关键词
重症肺炎/中性粒细胞计数/淋巴细胞计数比值/白细胞分化抗原64指数/诊断价值Key words
severe pneumonia/neutrophil count/lymphocyte count ratio/leukocyte differentiation an-tigen 64 index/diagnostic value分类
医药卫生引用本文复制引用
解拥军,王雯,朱蕾,高毅..血清NLR、CD64指数对重症肺炎的诊断价值[J].检验医学与临床,2025,22(17):2305-2309,2315,6.基金项目
中华国际医学交流基金会脑血管病青年创新基金项目(Z-2016-20-2101-15). （Z-2016-20-2101-15）
