检验医学与临床2025，Vol.22Issue(17)：2310-2315,6.DOI:10.3969/j.issn.1672-9455.2025.17.002
RMPP、MPP患儿血清IL-18、CysLTs、autotaxin水平及三者对MPP患儿发生RMPP的诊断价值
The levels of serum IL-18,CysLTs and autotaxin in children with RMPP or MPP and their diagnostic value for RMPP in children with MPP
摘要
Abstract
Objective To investigate the levels of serum interleukin(IL)-18,cysteinyl leukotrienes(Cys-LTs)and autotaxin in children with refractory Mycoplasma pneumoniae pneumonia(RMPP)or Mycoplasma pneumoniae pneumonia(MPP)and their diagnostic value for RMPP in children with MPP.Methods A total of 152 children with MPP admitted to the hospital from September 2021 to June 2023 were selected as the re-search objects.According to whether RMPP occurred,they were divided into RMPP group(76 cases)and MPP group(76 cases).The severity of MPP was evaluated,and the mild children were included in the mild group,the severe children were included in the severe group,and the critical children were included in the criti-cal group.Clinical data of all subjects were collected.The serum levels of IL-18,CysLTs and autotaxin in the subjects were detected.Multivariate Logistic regression was used to analyze the influencing factors of RMPP in children with MPP.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of serum IL-18,CysLTs and autotaxin alone and in combination of 3 items for RMPP in children with MPP.Spearman correlation was used to analyze the correlation between serum IL-18,CysLTs,autotaxin levels and disease severity in children with MPP.Results The serum levels of IL-18,CysLTs and autotaxin in the RMPP group were higher than those in the MPP group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that the increased serum levels of IL-18,CysLTs and autotaxin were risk factors for RMPP in children with MPP(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum IL-18,CysLTs and autotaxin for diagnosing RMPP in children with MPP were 0.799,0.799 and 0.812 respectively,all of them were lower than the AUC of the combined detec-tion of the 3 items in diagnosing RMPP in children with MPP(Z=8.256,8.294,9.020,P＜0.05).There were 50 patients in the mild group,58 patients in the severe group,and 44 patients in the critical group.The levels of serum IL-18,CysLTs and autotaxin in the mild group were lower than those in the severe group and the critical group,and those in the severe group were lower than those in the critical group,and the differences were statistically significant(P＜0.05).Spearman correlation analysis showed that the serum levels of IL-18,CysLTs and autotaxin in children with MPP were positively correlated with the severity of the disease(rs=0.732,0.723,0.729,P＜0.05).Conclusion Serum IL-18,CysLTs and autotaxin are related to the occurrence of RMPP and severity of MPP.The combined detection of IL-18,CysLTs and autotaxin has a certain diagnos-tic value for RMPP,which can be used as an auxiliary indicator for clinical judgment of the condition of MPP and early identification of RMPP,and can guide clinical decision-making.关键词
肺炎支原体肺炎/难治性肺炎支原体肺炎/白细胞介素-18/半胱氨酰白三烯/自分泌运动因子/相关性Key words
Mycoplasma pneumoniae pneumonia/refractory mycoplasma pneumoniae pneumonia/in-terleukin-18/cysteinyl leukotriene/autocrine motility factor/relevance分类
医药卫生引用本文复制引用
刘连凤,杨真真,杜杰静..RMPP、MPP患儿血清IL-18、CysLTs、autotaxin水平及三者对MPP患儿发生RMPP的诊断价值[J].检验医学与临床,2025,22(17):2310-2315,6.基金项目
河北省医学科学研究课题(20210283). （20210283）
