检验医学与临床2025，Vol.22Issue(17)：2321-2326,2334,7.DOI:10.3969/j.issn.1672-9455.2025.17.004
血清IL-1R1、SDF-1水平联合检测对儿童社区获得性肺炎的临床诊断价值
Clinical diagnostic value of combined detection of serum IL-1R1 and SDF-1 levels in children with community-acquired pneumonia
摘要
Abstract
Objective To explore the clinical diagnostic value of combined detection of serum interleukin-1 receptor type 1(IL-1R1)and stromal cell-derived factor-1(SDF-1)levels in children with community-ac-quired pneumonia(CAP).Methods A total of 229 children with CAP admitted to the hospital from March 2022 to April 2024 were selected as the study group.The study group was divided into the mild group and the severe group according to the severity of the children's conditions.A total of 229 healthy children who under-went physical examination in the hospital during the same period were selected as the control group.Lympho-cyte count(Lym),white blood cell count(WBC),monocyte count(Mon),platelet count(PLT),aspartate aminotransferase(AST)and levels of alanine aminotransferase(ALT),C reactive protein(CRP),procalcito-nin(PCT),myoglobin(MB),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH)were detec-ted,meanwhile,the Mon/Lym ratio(MLR)and PLT/Lym ratio(PLR)were calculated.Pearson correlation was used to analyze the correlation between laboratory indicators and serum levels of IL-1R1 and SDF-1 in children with severe CAP.Multivariate Logistic regression was used to analyze the influencing factors for pro-gression to severe condition in children with CAP.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum IL-1R1,SDF-1 alone and combined detection for progression to severe condition in children with CAP.Results The serum levels of IL-1R1 and SDF-1 in the study group were significantly higher than those in the control group(P＜0.05).The WBC,Mon,PLR,MLR and levels of AST,CRP,PCT,Mb,CK-MB and LDH in the study group were higher than those in the control group,and the levels of Lym and PLT were lower than those in the control group,and the differences were statistically significant(P＜0.05).There were 151 patients in the mild group and 78 patients in the severe group.The PLR,MLR and serum levels of IL-1R1,SDF-1,CRP,PCT,LDH in the severe group were higher than those in the mild group,and Lym was lower than that in the mild group,and the differences were statistically signifi-cant(P＜0.05).Pearson correlation analysis showed that serum IL-1R1 level was positively correlated with SDF-1 level(P＜0.05).Serum IL-1R1 and SDF-1 levels were negatively correlated with Lym(P＜0.05),and positively correlated with PLR,MLR and levels of CRP,PCT,LDH(P＜0.05).Multivariate Logistic regres-sion analysis showed that increased PLR,MLR,IL-1R1,SDF-1,CRP,PCT,LDH were risk factors for progres-sion to severe condition in children with CAP(P＜0.05),and increased Lym was protective factor for pro-gression to severe condition in children with CAP(P＜0.05).ROC curve analysis showed that the area under the curve(AUC)of serum IL-1R1 and SDF-1 in the diagnosis of progression to severe condition in children with CAP was 0.855 and 0.810 respectively,and the AUC of combined detection of the two was 0.892,which was greater than that of IL-1R1 or SDF-1 alone(Z=2.685,2.703,P＜0.05).Conclusion The serum levels of IL-1R1 and SDF-1 in children with CAP are significantly increased,and their combined detection has high clinical value in the diagnosis of children with CAP.关键词
白细胞介素-1受体1/基质细胞衍生因子-1/儿童社区获得性肺炎/病情严重程度/诊断价值Key words
interleukin-1 receptor type 1/stromal cell-derived factor-1/community-acquired pneumo-nia in children/severity of illness/diagnostic value分类
医药卫生引用本文复制引用
王思雅,范艳平,秦惠何,彭及城,何金凤,阳建..血清IL-1R1、SDF-1水平联合检测对儿童社区获得性肺炎的临床诊断价值[J].检验医学与临床,2025,22(17):2321-2326,2334,7.基金项目
广东省深圳市宝安区医疗卫生科研项目(2023JD221). （2023JD221）
