检验医学与临床2025，Vol.22Issue(17)：2340-2345,6.DOI:10.3969/j.issn.1672-9455.2025.17.007
血清PI3K mRNA、Akt mRNA水平与老年冠心病心力衰竭患者病情严重程度的相关性
Correlation between serum PI3K mRNA and Akt mRNA levels and the severity of heart failure in elderly patients with coronary heart disease
摘要
Abstract
Objective To investigate the correlation between serum phosphatidylinositol 3-kinase(PI3K)mRNA,protein-serine-threonine(Akt)mRNA levels and the severity of heart failure in elderly patients with coronary heart disease.Methods A total of 104 patients with coronary heart disease and heart failure who were treated in the First Affiliated Hospital of Anhui Medical University from January 2023 to January 2024 were selected as the case group.In addition,52 healthy volunteers who underwent physical examination in the First Affiliated Hospital of Anhui Medical University during the same period were selected as the control group.According to the New York Heart Association classification,all patients were divided into class Ⅱ group,class Ⅲ group and class Ⅳ group.The levels of serum PI3K mRNA and Akt mRNA were compared between the case group and the control group,and among the class Ⅱ,class Ⅲ and class Ⅳ groups.Pearson correlation analysis was used to analyze the correlation between serum PI3K mRNA,Akt mRNA levels and C reactive protein(CRP),tumor necrosis factor-a(TNF-α),interleukin(IL)-6,IL-1β levels in the case group.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum PI3K mR-NA,Akt mRNA alone and combined detection for the aggravation of coronary heart disease in patients with heart failure.Results The levels of CRP,TNF-α,IL-1β,IL-6,PI3K mRNA and Akt mRNA in the case group were higher than those in the control group,and the differences were statistically significant(P＜0.05).There were 35 patients in class Ⅱ group,37 patients in class Ⅲ group and 32 patients in class Ⅳ group.The levels of serum CRP,TNF-α,IL-1β,IL-6,PI3K mRNA and Akt mRNA in the class Ⅱ group were lower than those in the class Ⅲ group and the class Ⅳ group,and the class Ⅲgroup was lower than the class Ⅳ group,and the differences were statistically significant(P＜0.05).The serum levels of PI3K mRNA and Akt mRNA were positively correlated with the levels of CRP,TNF-α,IL-1β and IL-6 in the case group(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of serum PI3K mRNA and Akt mRNA in the diagnosis of aggravation of coronary heart disease patients with heart failure was 0.877 and 0.803 respec-tively,which was less than the AUC of combined detection of the two in predicting the aggravation of coro-nary heart disease patients with heart failure(P＜0.05).Conclusion The levels of PI3K mRNA and Akt mRNA in serum of patients with coronary heart disease and heart failure are increased,which are positively correlated with the levels of inflammatory factors.The combined detection of PI3K mRNA and Akt mRNA has a high predictive value for the aggravation of coronary artery lesions in patients with coronary heart dis-ease and heart failure.关键词
老年/冠心病心力衰竭/磷酸肌醇3激酶/蛋白质丝氨酸苏氨酸/冠脉病变/相关性Key words
elderly age/coronary heart disease with heart failure/phosphatidylinositol 3-kinase/pro-tein serine threonine/coronary artery disease/correlation分类
医药卫生引用本文复制引用
樊娟,李洁华,王芊瑶,张奇,张艺..血清PI3K mRNA、Akt mRNA水平与老年冠心病心力衰竭患者病情严重程度的相关性[J].检验医学与临床,2025,22(17):2340-2345,6.基金项目
安徽省自然科学基金项目(2022085QH209). （2022085QH209）
